Phagocytosis in phosphate chromium (III) suspensions

• Main Authors: Jorge Cruz Arencibia, Yoiz Fano Machín, Amed Cruz Morales, Radamés Tamayo Fuente, José Morín Zorrilla
• Format: Article
• Language: English
• Published: Centro de Gestión de la Información y Desarrollo de la Energía (CUBAENERGIA) 2015-01-01
• Series: Nucleus
• Subjects: fagocitosis; radiofármacos; fosfatos de cromo; articulaciones de los huesos; enfermedades reumáticas
• Online Access: http://nucleus.cubaenergia.cu/index.php/nucleus/article/view/600

Phagocytosis in vivo and in vitro of a suspension of chromic phosphate (III) labeled with and is studied. The radioactive particles dispersed in a media of 2 % gelatin in acetate buffer pH 4-4.5 have a predominant size of 0.8 μm and 5 μm. According with biodistribution experiments in rats after 30 minutes near the 80 % of radioactivity is registered in the liver, probably associated with phagocytosis of the particles by liver Kupffer cells. Is also showed that the suspension particles are phagocytized in vitro by mouse peritoneal macrophages. This facts indicate that the studied suspension have appropriate characteristics to be used in adiosynoviorthesis according to the principal action mechanism described for this procedure, particles phagocytosis by cells present in the inflamed synovium.