Low Expression Levels of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gastric Cancer and its Relationship with Tumor Progression
Background: Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in hindering the progression and growth of cancer cells. The function of PPARγ in gastric cancer and its relationship with progression of the disease have not been appropriately defined. Therefore, this study e...
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doaj-da6f350d6dda4f7ca5561c6e788d5cf12020-11-25T01:08:57ZfasVesnu Publications مجله دانشکده پزشکی اصفهان1027-75951735-854X2017-09-01354409119182604Low Expression Levels of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gastric Cancer and its Relationship with Tumor ProgressionGholam Basati0Hadiseh Mohammadpour1Amirnader Emami-Razavi2Associate Professor, Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, IranCancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranPhD, Iran National Tumor Bank, Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranBackground: Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in hindering the progression and growth of cancer cells. The function of PPARγ in gastric cancer and its relationship with progression of the disease have not been appropriately defined. Therefore, this study examined the association of PPARγ expression in tumor with advancement of gastric cancer. Methods: In the cross-sectional case-control study, the expression of PPARγ in tumoral and the paired adjacent normal tissues of 50 patients with gastric cancer, who undergone tumor resection at Institute of Imam Khomeini University Hospital, Tehran, Iran, were assayed and compared using quantitative real-time polymerase chain reaction method. Correlation between PPARγ expression in tumor tissue and the cancer progression relevant clinicopathological features was evaluated using the Spearman’s rho correlation test. Findings: The relative expression levels of PPARγ in tumoral tissues were shown to be profoundly decreased compared with their adjacent normal tissues [0.36 (0.15-0.89) vs. 1.01 (0.83-1.16), P < 0.001]. There was significant correlation between the relative expression level of PPARγ in tumoral tissues and clinicopathological features such as cancer staging, tumor differentiation, tumor size, and lymphatic and vascular invasion. However, there was no noticeable correlation between the relative PPARγ expression level and other features such as age, gender, and metastasis. Conclusion: Decreased expression of PPARγ in gastric cancer tissue compared to the adjacent normal tissues is inversely associated with the cancer progression and development relevant clinicopathological features; hence, it may play an important role in the pathophysiology of gastric cancer.http://jims.mui.ac.ir/index.php/jims/article/view/8413PPAR gammaGastric cancerCancer stagingDisease progression |
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language |
fas |
format |
Article |
sources |
DOAJ |
author |
Gholam Basati Hadiseh Mohammadpour Amirnader Emami-Razavi |
spellingShingle |
Gholam Basati Hadiseh Mohammadpour Amirnader Emami-Razavi Low Expression Levels of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gastric Cancer and its Relationship with Tumor Progression مجله دانشکده پزشکی اصفهان PPAR gamma Gastric cancer Cancer staging Disease progression |
author_facet |
Gholam Basati Hadiseh Mohammadpour Amirnader Emami-Razavi |
author_sort |
Gholam Basati |
title |
Low Expression Levels of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gastric Cancer and its Relationship with Tumor Progression |
title_short |
Low Expression Levels of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gastric Cancer and its Relationship with Tumor Progression |
title_full |
Low Expression Levels of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gastric Cancer and its Relationship with Tumor Progression |
title_fullStr |
Low Expression Levels of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gastric Cancer and its Relationship with Tumor Progression |
title_full_unstemmed |
Low Expression Levels of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gastric Cancer and its Relationship with Tumor Progression |
title_sort |
low expression levels of peroxisome proliferator-activated receptor gamma (pparγ) in gastric cancer and its relationship with tumor progression |
publisher |
Vesnu Publications |
series |
مجله دانشکده پزشکی اصفهان |
issn |
1027-7595 1735-854X |
publishDate |
2017-09-01 |
description |
Background: Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in hindering the progression and growth of cancer cells. The function of PPARγ in gastric cancer and its relationship with progression of the disease have not been appropriately defined. Therefore, this study examined the association of PPARγ expression in tumor with advancement of gastric cancer.
Methods: In the cross-sectional case-control study, the expression of PPARγ in tumoral and the paired adjacent normal tissues of 50 patients with gastric cancer, who undergone tumor resection at Institute of Imam Khomeini University Hospital, Tehran, Iran, were assayed and compared using quantitative real-time polymerase chain reaction method. Correlation between PPARγ expression in tumor tissue and the cancer progression relevant clinicopathological features was evaluated using the Spearman’s rho correlation test.
Findings: The relative expression levels of PPARγ in tumoral tissues were shown to be profoundly decreased compared with their adjacent normal tissues [0.36 (0.15-0.89) vs. 1.01 (0.83-1.16), P < 0.001]. There was significant correlation between the relative expression level of PPARγ in tumoral tissues and clinicopathological features such as cancer staging, tumor differentiation, tumor size, and lymphatic and vascular invasion. However, there was no noticeable correlation between the relative PPARγ expression level and other features such as age, gender, and metastasis.
Conclusion: Decreased expression of PPARγ in gastric cancer tissue compared to the adjacent normal tissues is inversely associated with the cancer progression and development relevant clinicopathological features; hence, it may play an important role in the pathophysiology of gastric cancer. |
topic |
PPAR gamma Gastric cancer Cancer staging Disease progression |
url |
http://jims.mui.ac.ir/index.php/jims/article/view/8413 |
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