Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1
Hsf1 is an ancient transcription factor that responds to protein folding stress by inducing the heat-shock response (HSR) that restore perturbed proteostasis. Hsp70 chaperones negatively regulate the activity of Hsf1 via stress-responsive mechanisms that are poorly understood. Here, we have reconsti...
Main Authors: | Anna E Masser, Wenjing Kang, Joydeep Roy, Jayasankar Mohanakrishnan Kaimal, Jany Quintana-Cordero, Marc R Friedländer, Claes Andréasson |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-09-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/47791 |
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