Antioxidants Present in Reproductive Tract Fluids and Their Relevance for Fertility

• Main Authors: João C. Ribeiro, Patrícia C. Braga, Ana D. Martins, Branca M. Silva, Marco G. Alves, Pedro F. Oliveira
• Format: Article
• Language: English
• Published: MDPI AG 2021-09-01
• Series: Antioxidants
• Subjects: antioxidants; fertility couple; reactive oxygen species; female reproductive fluid; seminal plasma; sperm parameters
• Online Access: https://www.mdpi.com/2076-3921/10/9/1441

Nowadays, infertility is classified as a disease of the reproductive system. Although it does not compromise the life of the individual, it can have detrimental effects on the physiological and psychological health of the couple. Male fertility evaluation is mainly focused on the analysis of sperm parameters. However, the ejaculated fluid is also composed of seminal plasma, and the study of this fluid can provide crucial information to help in the assessment of male fertility status. Total antioxidant capacity of the seminal plasma has been positively correlated with the fertility of men. Moreover, evidence highlights to a similar importance as that of female reproductive tract fluid antioxidant capabilities and female fertility. Herein, we describe the functions of seminal plasma and female reproductive tract fluids, as well as their main antioxidant components and their relationships with fertility outcomes. Additionally, this review contains the most up to date information regarding the mechanisms of the interaction between the male and the female reproductive fluids and the importance of proper antioxidant capacity for fertilization.