Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s disease
Abstract Objective The objectives of this study were to investigate whether the plasma levels of oligomeric amyloid-β (OAβ) were affected in Alzheimer’s disease (AD) and to examine the associations (or possible correlations) between plasma OAβ levels and memory performance. Method Thirty subjects wi...
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2019-10-01
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Series: | Alzheimer’s Research & Therapy |
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Online Access: | http://link.springer.com/article/10.1186/s13195-019-0535-7 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xue Meng Tao Li Xiao Wang Xiaozhen Lv Zhiyu Sun Jichun Zhang Feng Su Sungmin Kang SangYun Kim Seong Soo A. An Xin Yu Chen Zhang Huali Wang |
spellingShingle |
Xue Meng Tao Li Xiao Wang Xiaozhen Lv Zhiyu Sun Jichun Zhang Feng Su Sungmin Kang SangYun Kim Seong Soo A. An Xin Yu Chen Zhang Huali Wang Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s disease Alzheimer’s Research & Therapy Alzheimer’s disease Amyloid oligomers Plasma Episodic memory |
author_facet |
Xue Meng Tao Li Xiao Wang Xiaozhen Lv Zhiyu Sun Jichun Zhang Feng Su Sungmin Kang SangYun Kim Seong Soo A. An Xin Yu Chen Zhang Huali Wang |
author_sort |
Xue Meng |
title |
Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s disease |
title_short |
Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s disease |
title_full |
Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s disease |
title_fullStr |
Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s disease |
title_full_unstemmed |
Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s disease |
title_sort |
association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in alzheimer’s disease |
publisher |
BMC |
series |
Alzheimer’s Research & Therapy |
issn |
1758-9193 |
publishDate |
2019-10-01 |
description |
Abstract Objective The objectives of this study were to investigate whether the plasma levels of oligomeric amyloid-β (OAβ) were affected in Alzheimer’s disease (AD) and to examine the associations (or possible correlations) between plasma OAβ levels and memory performance. Method Thirty subjects with AD and 28 cognitively normal controls were recruited in the study. The multimer detection system (MDS) was used to measure the levels of OAβ in the plasma. In addition to assessing the general cognitive function with the Mini-Mental State Examination (MMSE), Cognitive Abilities Screening Instrument (CASI), and Alzheimer’s Disease Assessment Scale–cognitive portion (ADAS-Cog), the common objects memory test (COMT) was used to examine the episodic memory performance. Pearson’s and partial correlation analyses were conducted to explore the associations between cognitive performance and OAβ levels in the plasma. A receiving operating curve (ROC) analysis was used to discriminate between the AD and control groups. Results The plasma OAβ levels in the AD group were significantly higher than those in the control group [1.88 (0.38) ng/ml vs 1.20 (0.40) ng/ml, p < 0.001]. The elevated levels of plasma OAβ showed a strong correlation with cognitive performance in patients with AD, including an inverse correlation with scores on the MMSE (r = − 0.43, p = 0.02), CASI (r = − 0.56, p < 0.01), and the immediate recall (r = − 0.45, p = 0.01), 5-min delayed recall (r = − 0.56, p < 0.01), and 30-min delayed recall (r = − 0.71, p < 0.001) tests of the COMT, and a positive correlation with the ADAS-Cog scores (r = 0.59, p < 0.001). The EDTA plasma Aβ oligomer optical density (OD) value measured using the MDS could discriminate between the AD and control groups with an area under the curve (AUC) of 0.89. The optimal sensitivity and specificity were 82.1% and 90.0%, respectively. Conclusion The elevated levels of OAβ in the plasma distinguished the AD and control groups and were associated with the severity of symptoms, especially memory performance, in patients with AD. Our results suggested that plasma OAβ could potentially be a simple and non-invasive blood-based biomarker for AD diagnosis. Furthermore, longitudinal studies are warranted to explore the application of plasma OAβ levels as a valid diagnostic biomarker in patients with AD. |
topic |
Alzheimer’s disease Amyloid oligomers Plasma Episodic memory |
url |
http://link.springer.com/article/10.1186/s13195-019-0535-7 |
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doaj-da86ea4aabb849a08212b251b4a87a2b2020-11-25T03:40:44ZengBMCAlzheimer’s Research & Therapy1758-91932019-10-0111111010.1186/s13195-019-0535-7Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s diseaseXue Meng0Tao Li1Xiao Wang2Xiaozhen Lv3Zhiyu Sun4Jichun Zhang5Feng Su6Sungmin Kang7SangYun Kim8Seong Soo A. An9Xin Yu10Chen Zhang11Huali Wang12Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital)Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital)Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital)Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital)Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital)Dementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital)State Key Laboratory of Membrane Biology, School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking UniversityDepartment of Research and Development, PeopleBio, Inc.Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of MedicineDepartment of Bionano Technology, Gachon UniversityDementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital)State Key Laboratory of Membrane Biology, School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking UniversityDementia Care and Research Center, Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia, Peking University Institute of Mental Health (Sixth Hospital)Abstract Objective The objectives of this study were to investigate whether the plasma levels of oligomeric amyloid-β (OAβ) were affected in Alzheimer’s disease (AD) and to examine the associations (or possible correlations) between plasma OAβ levels and memory performance. Method Thirty subjects with AD and 28 cognitively normal controls were recruited in the study. The multimer detection system (MDS) was used to measure the levels of OAβ in the plasma. In addition to assessing the general cognitive function with the Mini-Mental State Examination (MMSE), Cognitive Abilities Screening Instrument (CASI), and Alzheimer’s Disease Assessment Scale–cognitive portion (ADAS-Cog), the common objects memory test (COMT) was used to examine the episodic memory performance. Pearson’s and partial correlation analyses were conducted to explore the associations between cognitive performance and OAβ levels in the plasma. A receiving operating curve (ROC) analysis was used to discriminate between the AD and control groups. Results The plasma OAβ levels in the AD group were significantly higher than those in the control group [1.88 (0.38) ng/ml vs 1.20 (0.40) ng/ml, p < 0.001]. The elevated levels of plasma OAβ showed a strong correlation with cognitive performance in patients with AD, including an inverse correlation with scores on the MMSE (r = − 0.43, p = 0.02), CASI (r = − 0.56, p < 0.01), and the immediate recall (r = − 0.45, p = 0.01), 5-min delayed recall (r = − 0.56, p < 0.01), and 30-min delayed recall (r = − 0.71, p < 0.001) tests of the COMT, and a positive correlation with the ADAS-Cog scores (r = 0.59, p < 0.001). The EDTA plasma Aβ oligomer optical density (OD) value measured using the MDS could discriminate between the AD and control groups with an area under the curve (AUC) of 0.89. The optimal sensitivity and specificity were 82.1% and 90.0%, respectively. Conclusion The elevated levels of OAβ in the plasma distinguished the AD and control groups and were associated with the severity of symptoms, especially memory performance, in patients with AD. Our results suggested that plasma OAβ could potentially be a simple and non-invasive blood-based biomarker for AD diagnosis. Furthermore, longitudinal studies are warranted to explore the application of plasma OAβ levels as a valid diagnostic biomarker in patients with AD.http://link.springer.com/article/10.1186/s13195-019-0535-7Alzheimer’s diseaseAmyloid oligomersPlasmaEpisodic memory |