Edible Bird’s Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression
Menopause causes cognitive and memory dysfunction due to impaired neuronal plasticity in the hippocampus. Sirtuin-1 (SIRT1) downregulation in the hippocampus is implicated in the underlying molecular mechanism. Edible bird’s nest (EBN) is traditionally used to improve general wellbeing, and in this...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2017-01-01
|
Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2017/7205082 |
id |
doaj-da9935e988b543b980161b221b062ba3 |
---|---|
record_format |
Article |
spelling |
doaj-da9935e988b543b980161b221b062ba32020-11-24T22:40:33ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942017-01-01201710.1155/2017/72050827205082Edible Bird’s Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 ExpressionZhiping Hou0Peiyuan He1Mustapha Umar Imam2Jiemen Qi3Shiying Tang4Chengjun Song5Maznah Ismail6Department of Pathology, Chengde Medical University, Chengde, Hebei 067000, ChinaGastroenterology Department, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, ChinaLaboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Pathology, Chengde Medical University, Chengde, Hebei 067000, ChinaDepartment of Pathology, Chengde Medical University, Chengde, Hebei 067000, ChinaDepartment of Pathology, Chengde Medical University, Chengde, Hebei 067000, ChinaLaboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaMenopause causes cognitive and memory dysfunction due to impaired neuronal plasticity in the hippocampus. Sirtuin-1 (SIRT1) downregulation in the hippocampus is implicated in the underlying molecular mechanism. Edible bird’s nest (EBN) is traditionally used to improve general wellbeing, and in this study, we evaluated its effects on SIRT1 expression in the hippocampus and implications on ovariectomy-induced memory and cognitive decline in rats. Ovariectomized female Sprague-Dawley rats were fed with normal pellet alone or normal pellet + EBN (6, 3, or 1.5%), compared with estrogen therapy (0.2 mg/kg/day). After 12 weeks of intervention, Morris water maze (four-day trial and one probe trial) was conducted, and serum estrogen levels, toxicity markers (alanine transaminase, alkaline phosphatase, urea, and creatinine), and hippocampal SIRT1 immunohistochemistry were estimated after sacrifice. The results indicated that EBN and estrogen enhanced spatial learning and memory and increased serum estrogen and hippocampal SIRT1 expression. In addition, the EBN groups did not show as much toxicity to the liver as the estrogen group. The data suggested that EBN treatment for 12 weeks could improve cognition and memory in ovariectomized female rats and may be an effective alternative to estrogen therapy for menopause-induced aging-related memory loss.http://dx.doi.org/10.1155/2017/7205082 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhiping Hou Peiyuan He Mustapha Umar Imam Jiemen Qi Shiying Tang Chengjun Song Maznah Ismail |
spellingShingle |
Zhiping Hou Peiyuan He Mustapha Umar Imam Jiemen Qi Shiying Tang Chengjun Song Maznah Ismail Edible Bird’s Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression Oxidative Medicine and Cellular Longevity |
author_facet |
Zhiping Hou Peiyuan He Mustapha Umar Imam Jiemen Qi Shiying Tang Chengjun Song Maznah Ismail |
author_sort |
Zhiping Hou |
title |
Edible Bird’s Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression |
title_short |
Edible Bird’s Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression |
title_full |
Edible Bird’s Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression |
title_fullStr |
Edible Bird’s Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression |
title_full_unstemmed |
Edible Bird’s Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression |
title_sort |
edible bird’s nest prevents menopause-related memory and cognitive decline in rats via increased hippocampal sirtuin-1 expression |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2017-01-01 |
description |
Menopause causes cognitive and memory dysfunction due to impaired neuronal plasticity in the hippocampus. Sirtuin-1 (SIRT1) downregulation in the hippocampus is implicated in the underlying molecular mechanism. Edible bird’s nest (EBN) is traditionally used to improve general wellbeing, and in this study, we evaluated its effects on SIRT1 expression in the hippocampus and implications on ovariectomy-induced memory and cognitive decline in rats. Ovariectomized female Sprague-Dawley rats were fed with normal pellet alone or normal pellet + EBN (6, 3, or 1.5%), compared with estrogen therapy (0.2 mg/kg/day). After 12 weeks of intervention, Morris water maze (four-day trial and one probe trial) was conducted, and serum estrogen levels, toxicity markers (alanine transaminase, alkaline phosphatase, urea, and creatinine), and hippocampal SIRT1 immunohistochemistry were estimated after sacrifice. The results indicated that EBN and estrogen enhanced spatial learning and memory and increased serum estrogen and hippocampal SIRT1 expression. In addition, the EBN groups did not show as much toxicity to the liver as the estrogen group. The data suggested that EBN treatment for 12 weeks could improve cognition and memory in ovariectomized female rats and may be an effective alternative to estrogen therapy for menopause-induced aging-related memory loss. |
url |
http://dx.doi.org/10.1155/2017/7205082 |
work_keys_str_mv |
AT zhipinghou ediblebirdsnestpreventsmenopauserelatedmemoryandcognitivedeclineinratsviaincreasedhippocampalsirtuin1expression AT peiyuanhe ediblebirdsnestpreventsmenopauserelatedmemoryandcognitivedeclineinratsviaincreasedhippocampalsirtuin1expression AT mustaphaumarimam ediblebirdsnestpreventsmenopauserelatedmemoryandcognitivedeclineinratsviaincreasedhippocampalsirtuin1expression AT jiemenqi ediblebirdsnestpreventsmenopauserelatedmemoryandcognitivedeclineinratsviaincreasedhippocampalsirtuin1expression AT shiyingtang ediblebirdsnestpreventsmenopauserelatedmemoryandcognitivedeclineinratsviaincreasedhippocampalsirtuin1expression AT chengjunsong ediblebirdsnestpreventsmenopauserelatedmemoryandcognitivedeclineinratsviaincreasedhippocampalsirtuin1expression AT maznahismail ediblebirdsnestpreventsmenopauserelatedmemoryandcognitivedeclineinratsviaincreasedhippocampalsirtuin1expression |
_version_ |
1725704533158395904 |