The effects of age and the expression of SPARC on extracellular matrix production by cardiac fibroblasts in 3-D cultures.
Fibrillar collagen is the primary component of the cardiac interstitial extracellular matrix. This extracellular matrix undergoes dramatic changes from birth to adulthood and then into advanced age. As evidence, fibrillar collagen content was compared in sections from neonates, adult, and old hearts...
Main Authors: | Jessica Trombetta-eSilva, Erik P Eadie, Yuhua Zhang, Russell A Norris, Thomas K Borg, Amy D Bradshaw |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3819255?pdf=render |
Similar Items
-
SPARC and the N-propeptide of collagen I influence fibroblast proliferation and collagen assembly in the periodontal ligament.
by: Emilie Moore Rosset, et al.
Published: (2017-01-01) -
Age and SPARC Change the Extracellular Matrix Composition of the Left Ventricle
by: Lisandra E. de Castro Brás, et al.
Published: (2014-01-01) -
Implication of SPARC in the modulation of the extracellular matrix and mitochondrial function in muscle cells.
by: Aicha Melouane, et al.
Published: (2018-01-01) -
β3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse.
by: Sundaravadivel Balasubramanian, et al.
Published: (2012-01-01) -
Cardiac Fibroblasts and the Extracellular Matrix in Regenerative and Nonregenerative Hearts
by: Luis Hortells, et al.
Published: (2019-08-01)