Water permeability is a measure of severity in acute appendicitis
Acute appendicitis is the most common indication for pediatric abdominal emergency surgery. Determination of the severity of appendicitis on clinical grounds is challenging. Complicated appendicitis presenting with perforation, abscess or diffuse peritonitis is not uncommon. The question remains why...
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Online Access: | http://dx.doi.org/10.1080/14756366.2017.1347167 |
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doaj-dac2e616b06442b2a4c128f6c48259d22020-11-25T02:36:19ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742017-01-013211036104110.1080/14756366.2017.13471671347167Water permeability is a measure of severity in acute appendicitisNicola Pini0Viktoria A. Pfeifle1Urs Kym2Simone Keck3Virginie Galati4Stefan Holland-Cunz5Stephanie J. Gros6University Childrens’ Hospital of Basel (UKBB)University Childrens’ Hospital of Basel (UKBB)University Childrens’ Hospital of Basel (UKBB)University Childrens’ Hospital of Basel (UKBB)University Childrens’ Hospital of Basel (UKBB)University Childrens’ Hospital of Basel (UKBB)University Childrens’ Hospital of Basel (UKBB)Acute appendicitis is the most common indication for pediatric abdominal emergency surgery. Determination of the severity of appendicitis on clinical grounds is challenging. Complicated appendicitis presenting with perforation, abscess or diffuse peritonitis is not uncommon. The question remains why and when acute appendicitis progresses to perforation. The aim of this study was to assess the impact of water permeability on the severity of appendicitis. We show that AQP1 expression and water permeability in appendicitis correlate with the stage of inflammation and systemic infection parameters, leading eventually to perforation of the appendix. AQP1 is also expressed within the ganglia of the enteric nervous system and ganglia count increases with inflammation. Severity of appendicitis can be correlated with water permeability measured by AQP1 protein expression and increase of ganglia count in a progressive manner. This introduces the question if regulation of water permeability can present novel curative or ameliorating therapeutic options.http://dx.doi.org/10.1080/14756366.2017.1347167Aquaporin 1water permeabilityenteric nervous systemappendicitispediatric surgery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicola Pini Viktoria A. Pfeifle Urs Kym Simone Keck Virginie Galati Stefan Holland-Cunz Stephanie J. Gros |
spellingShingle |
Nicola Pini Viktoria A. Pfeifle Urs Kym Simone Keck Virginie Galati Stefan Holland-Cunz Stephanie J. Gros Water permeability is a measure of severity in acute appendicitis Journal of Enzyme Inhibition and Medicinal Chemistry Aquaporin 1 water permeability enteric nervous system appendicitis pediatric surgery |
author_facet |
Nicola Pini Viktoria A. Pfeifle Urs Kym Simone Keck Virginie Galati Stefan Holland-Cunz Stephanie J. Gros |
author_sort |
Nicola Pini |
title |
Water permeability is a measure of severity in acute appendicitis |
title_short |
Water permeability is a measure of severity in acute appendicitis |
title_full |
Water permeability is a measure of severity in acute appendicitis |
title_fullStr |
Water permeability is a measure of severity in acute appendicitis |
title_full_unstemmed |
Water permeability is a measure of severity in acute appendicitis |
title_sort |
water permeability is a measure of severity in acute appendicitis |
publisher |
Taylor & Francis Group |
series |
Journal of Enzyme Inhibition and Medicinal Chemistry |
issn |
1475-6366 1475-6374 |
publishDate |
2017-01-01 |
description |
Acute appendicitis is the most common indication for pediatric abdominal emergency surgery. Determination of the severity of appendicitis on clinical grounds is challenging. Complicated appendicitis presenting with perforation, abscess or diffuse peritonitis is not uncommon. The question remains why and when acute appendicitis progresses to perforation. The aim of this study was to assess the impact of water permeability on the severity of appendicitis. We show that AQP1 expression and water permeability in appendicitis correlate with the stage of inflammation and systemic infection parameters, leading eventually to perforation of the appendix. AQP1 is also expressed within the ganglia of the enteric nervous system and ganglia count increases with inflammation. Severity of appendicitis can be correlated with water permeability measured by AQP1 protein expression and increase of ganglia count in a progressive manner. This introduces the question if regulation of water permeability can present novel curative or ameliorating therapeutic options. |
topic |
Aquaporin 1 water permeability enteric nervous system appendicitis pediatric surgery |
url |
http://dx.doi.org/10.1080/14756366.2017.1347167 |
work_keys_str_mv |
AT nicolapini waterpermeabilityisameasureofseverityinacuteappendicitis AT viktoriaapfeifle waterpermeabilityisameasureofseverityinacuteappendicitis AT urskym waterpermeabilityisameasureofseverityinacuteappendicitis AT simonekeck waterpermeabilityisameasureofseverityinacuteappendicitis AT virginiegalati waterpermeabilityisameasureofseverityinacuteappendicitis AT stefanhollandcunz waterpermeabilityisameasureofseverityinacuteappendicitis AT stephaniejgros waterpermeabilityisameasureofseverityinacuteappendicitis |
_version_ |
1724800750958149632 |