Sphingolipid-dependent Dscam sorting regulates axon segregation

Sphingolipid-dependent Dscam sorting regulates axon segregation

Little is known about the initial segregation of axonal and dendritic proteins during the differentiation of newly generated neurons. Here authors use a forward genetic screen to identify the role of sphingolipids in regulating the sub-cellular distribution of Dscam for neuronal patterning in Drosop...

Full description

Bibliographic Details
Main Authors: Gaurav Goyal, Junfeng Zheng, Elisabeth Adam, Georg Steffes, Mamta Jain, Kristaps Klavins, Thomas Hummel
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08765-2
id doaj-dac65b4ee54f4d37850c41772c6a9f87
record_format Article
spelling doaj-dac65b4ee54f4d37850c41772c6a9f872021-05-11T11:51:02ZengNature Publishing GroupNature Communications2041-17232019-02-0110111710.1038/s41467-019-08765-2Sphingolipid-dependent Dscam sorting regulates axon segregationGaurav Goyal0Junfeng Zheng1Elisabeth Adam2Georg Steffes3Mamta Jain4Kristaps Klavins5Thomas Hummel6Department for Neurobiology, University of ViennaInstitut für Neuro- und Verhaltensbiologie, Universität MünsterDepartment for Neurobiology, University of ViennaInstitut für Neuro- und Verhaltensbiologie, Universität MünsterDivision of Cell and Developmental Biology, Centre for Anatomy and Cell Biology, Medical University of ViennaCeMM Research Centre for Molecular Medicine of the Austrian Academy of SciencesDepartment for Neurobiology, University of ViennaLittle is known about the initial segregation of axonal and dendritic proteins during the differentiation of newly generated neurons. Here authors use a forward genetic screen to identify the role of sphingolipids in regulating the sub-cellular distribution of Dscam for neuronal patterning in Drosophila Mushroom Bodieshttps://doi.org/10.1038/s41467-019-08765-2
collection DOAJ
language English
format Article
sources DOAJ
author Gaurav Goyal
Junfeng Zheng
Elisabeth Adam
Georg Steffes
Mamta Jain
Kristaps Klavins
Thomas Hummel
spellingShingle Gaurav Goyal
Junfeng Zheng
Elisabeth Adam
Georg Steffes
Mamta Jain
Kristaps Klavins
Thomas Hummel
Sphingolipid-dependent Dscam sorting regulates axon segregation
Nature Communications
author_facet Gaurav Goyal
Junfeng Zheng
Elisabeth Adam
Georg Steffes
Mamta Jain
Kristaps Klavins
Thomas Hummel
author_sort Gaurav Goyal
title Sphingolipid-dependent Dscam sorting regulates axon segregation
title_short Sphingolipid-dependent Dscam sorting regulates axon segregation
title_full Sphingolipid-dependent Dscam sorting regulates axon segregation
title_fullStr Sphingolipid-dependent Dscam sorting regulates axon segregation
title_full_unstemmed Sphingolipid-dependent Dscam sorting regulates axon segregation
title_sort sphingolipid-dependent dscam sorting regulates axon segregation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-02-01
description Little is known about the initial segregation of axonal and dendritic proteins during the differentiation of newly generated neurons. Here authors use a forward genetic screen to identify the role of sphingolipids in regulating the sub-cellular distribution of Dscam for neuronal patterning in Drosophila Mushroom Bodies
url https://doi.org/10.1038/s41467-019-08765-2
work_keys_str_mv AT gauravgoyal sphingolipiddependentdscamsortingregulatesaxonsegregation
AT junfengzheng sphingolipiddependentdscamsortingregulatesaxonsegregation
AT elisabethadam sphingolipiddependentdscamsortingregulatesaxonsegregation
AT georgsteffes sphingolipiddependentdscamsortingregulatesaxonsegregation
AT mamtajain sphingolipiddependentdscamsortingregulatesaxonsegregation
AT kristapsklavins sphingolipiddependentdscamsortingregulatesaxonsegregation
AT thomashummel sphingolipiddependentdscamsortingregulatesaxonsegregation
_version_ 1721445900394430464

Similar Items