Sphingolipid-dependent Dscam sorting regulates axon segregation
Little is known about the initial segregation of axonal and dendritic proteins during the differentiation of newly generated neurons. Here authors use a forward genetic screen to identify the role of sphingolipids in regulating the sub-cellular distribution of Dscam for neuronal patterning in Drosop...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-02-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-08765-2 |
id |
doaj-dac65b4ee54f4d37850c41772c6a9f87 |
---|---|
record_format |
Article |
spelling |
doaj-dac65b4ee54f4d37850c41772c6a9f872021-05-11T11:51:02ZengNature Publishing GroupNature Communications2041-17232019-02-0110111710.1038/s41467-019-08765-2Sphingolipid-dependent Dscam sorting regulates axon segregationGaurav Goyal0Junfeng Zheng1Elisabeth Adam2Georg Steffes3Mamta Jain4Kristaps Klavins5Thomas Hummel6Department for Neurobiology, University of ViennaInstitut für Neuro- und Verhaltensbiologie, Universität MünsterDepartment for Neurobiology, University of ViennaInstitut für Neuro- und Verhaltensbiologie, Universität MünsterDivision of Cell and Developmental Biology, Centre for Anatomy and Cell Biology, Medical University of ViennaCeMM Research Centre for Molecular Medicine of the Austrian Academy of SciencesDepartment for Neurobiology, University of ViennaLittle is known about the initial segregation of axonal and dendritic proteins during the differentiation of newly generated neurons. Here authors use a forward genetic screen to identify the role of sphingolipids in regulating the sub-cellular distribution of Dscam for neuronal patterning in Drosophila Mushroom Bodieshttps://doi.org/10.1038/s41467-019-08765-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gaurav Goyal Junfeng Zheng Elisabeth Adam Georg Steffes Mamta Jain Kristaps Klavins Thomas Hummel |
spellingShingle |
Gaurav Goyal Junfeng Zheng Elisabeth Adam Georg Steffes Mamta Jain Kristaps Klavins Thomas Hummel Sphingolipid-dependent Dscam sorting regulates axon segregation Nature Communications |
author_facet |
Gaurav Goyal Junfeng Zheng Elisabeth Adam Georg Steffes Mamta Jain Kristaps Klavins Thomas Hummel |
author_sort |
Gaurav Goyal |
title |
Sphingolipid-dependent Dscam sorting regulates axon segregation |
title_short |
Sphingolipid-dependent Dscam sorting regulates axon segregation |
title_full |
Sphingolipid-dependent Dscam sorting regulates axon segregation |
title_fullStr |
Sphingolipid-dependent Dscam sorting regulates axon segregation |
title_full_unstemmed |
Sphingolipid-dependent Dscam sorting regulates axon segregation |
title_sort |
sphingolipid-dependent dscam sorting regulates axon segregation |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-02-01 |
description |
Little is known about the initial segregation of axonal and dendritic proteins during the differentiation of newly generated neurons. Here authors use a forward genetic screen to identify the role of sphingolipids in regulating the sub-cellular distribution of Dscam for neuronal patterning in Drosophila Mushroom Bodies |
url |
https://doi.org/10.1038/s41467-019-08765-2 |
work_keys_str_mv |
AT gauravgoyal sphingolipiddependentdscamsortingregulatesaxonsegregation AT junfengzheng sphingolipiddependentdscamsortingregulatesaxonsegregation AT elisabethadam sphingolipiddependentdscamsortingregulatesaxonsegregation AT georgsteffes sphingolipiddependentdscamsortingregulatesaxonsegregation AT mamtajain sphingolipiddependentdscamsortingregulatesaxonsegregation AT kristapsklavins sphingolipiddependentdscamsortingregulatesaxonsegregation AT thomashummel sphingolipiddependentdscamsortingregulatesaxonsegregation |
_version_ |
1721445900394430464 |