β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancers
Abstract NQO1 is a FAD-binding protein that can form homodimers and reduce quinones to hydroquinones, and a growing body of evidence currently suggests that NQO1 is dramatically elevated in solid cancers. Here, we demonstrated that NQO1 was elevated in breast cancer and that its expression level was...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-06-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-02937-0 |
id |
doaj-dac6f61bcecb4c01adddd2d0c7f7a1f9 |
---|---|
record_format |
Article |
spelling |
doaj-dac6f61bcecb4c01adddd2d0c7f7a1f92020-12-08T01:14:56ZengNature Publishing GroupScientific Reports2045-23222017-06-017111310.1038/s41598-017-02937-0β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancersYang Yang0Xianchun Zhou1Ming Xu2Junjie Piao3Yuan Zhang4Zhenhua Lin5Liyan Chen6Department of Pathology & Cancer Research Center, Yanbian University Medical CollegeDepartment of Internal Medicine, Yanbian University HospitalDepartment of Pathology & Cancer Research Center, Yanbian University Medical CollegeDepartment of Pathology & Cancer Research Center, Yanbian University Medical CollegeDepartment of Pathology & Cancer Research Center, Yanbian University Medical CollegeDepartment of Pathology & Cancer Research Center, Yanbian University Medical CollegeDepartment of Pathology & Cancer Research Center, Yanbian University Medical CollegeAbstract NQO1 is a FAD-binding protein that can form homodimers and reduce quinones to hydroquinones, and a growing body of evidence currently suggests that NQO1 is dramatically elevated in solid cancers. Here, we demonstrated that NQO1 was elevated in breast cancer and that its expression level was positively correlated with invasion and reduced disease free survival (DFS) and overall survival (OS) rates. Next, we found that β-lapachone exerted significant anti-proliferation and anti-metastasis effects in breast cancer cell lines due to its effects on NQO1 expression. Moreover, we revealed that the anti-cancer effects of β-lapachone were mediated by the inactivation of the Akt/mTOR pathway. In conclusion, these results demonstrated that NQO1 could be a useful prognostic biomarker for patients with breast cancer, and its bioactivatable drug, β-lapachone represented a promising new development and an effective strategy for indicating the progression of NQO1-positive breast cancers.https://doi.org/10.1038/s41598-017-02937-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yang Yang Xianchun Zhou Ming Xu Junjie Piao Yuan Zhang Zhenhua Lin Liyan Chen |
spellingShingle |
Yang Yang Xianchun Zhou Ming Xu Junjie Piao Yuan Zhang Zhenhua Lin Liyan Chen β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancers Scientific Reports |
author_facet |
Yang Yang Xianchun Zhou Ming Xu Junjie Piao Yuan Zhang Zhenhua Lin Liyan Chen |
author_sort |
Yang Yang |
title |
β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancers |
title_short |
β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancers |
title_full |
β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancers |
title_fullStr |
β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancers |
title_full_unstemmed |
β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancers |
title_sort |
β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in nqo1-positive breast cancers |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-06-01 |
description |
Abstract NQO1 is a FAD-binding protein that can form homodimers and reduce quinones to hydroquinones, and a growing body of evidence currently suggests that NQO1 is dramatically elevated in solid cancers. Here, we demonstrated that NQO1 was elevated in breast cancer and that its expression level was positively correlated with invasion and reduced disease free survival (DFS) and overall survival (OS) rates. Next, we found that β-lapachone exerted significant anti-proliferation and anti-metastasis effects in breast cancer cell lines due to its effects on NQO1 expression. Moreover, we revealed that the anti-cancer effects of β-lapachone were mediated by the inactivation of the Akt/mTOR pathway. In conclusion, these results demonstrated that NQO1 could be a useful prognostic biomarker for patients with breast cancer, and its bioactivatable drug, β-lapachone represented a promising new development and an effective strategy for indicating the progression of NQO1-positive breast cancers. |
url |
https://doi.org/10.1038/s41598-017-02937-0 |
work_keys_str_mv |
AT yangyang blapachonesuppressestumourprogressionbyinhibitingepithelialtomesenchymaltransitioninnqo1positivebreastcancers AT xianchunzhou blapachonesuppressestumourprogressionbyinhibitingepithelialtomesenchymaltransitioninnqo1positivebreastcancers AT mingxu blapachonesuppressestumourprogressionbyinhibitingepithelialtomesenchymaltransitioninnqo1positivebreastcancers AT junjiepiao blapachonesuppressestumourprogressionbyinhibitingepithelialtomesenchymaltransitioninnqo1positivebreastcancers AT yuanzhang blapachonesuppressestumourprogressionbyinhibitingepithelialtomesenchymaltransitioninnqo1positivebreastcancers AT zhenhualin blapachonesuppressestumourprogressionbyinhibitingepithelialtomesenchymaltransitioninnqo1positivebreastcancers AT liyanchen blapachonesuppressestumourprogressionbyinhibitingepithelialtomesenchymaltransitioninnqo1positivebreastcancers |
_version_ |
1724395192518180864 |