HDAC inhibitors Tubastatin A and SAHA affect parasite cell division and are potential anti-Toxoplasma gondii chemotherapeutics

HDAC inhibitors Tubastatin A and SAHA affect parasite cell division and are potential anti-Toxoplasma gondii chemotherapeutics

The redirectioning of drugs in the pharmaceutical market is a well-known practice to identify new therapies for parasitic diseases. The histone deacetylase inhibitors Tubastatin A (TST) and Suberoylanilide Hydroxamic Acid (SAHA), firstly developed for cancer treatment, are effective against protozoa...

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Bibliographic Details
Main Authors: Carlla Assis Araujo-Silva, Wanderley De Souza, Erica S. Martins-Duarte, Rossiane C. Vommaro
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Toxoplasma gondii
Histone deacetylase inhibitors
Apicomplexa
Anti-parasitic chemotherapy
Endodyogeny
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320720300518

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