Coagulation Status in Dogs Naturally Infected with <i>Angiostrongylus vasorum</i>
<i>Angiostrongylus vasorum</i> infection has been associated with coagulopathies including hyperfibrinolysis. We compared coagulation status including thromboelastometry (ROTEM) parameters in dogs naturally infected with <i>A. vasorum</i> versus healthy dogs to determine clin...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | Pathogens |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-0817/10/9/1077 |
id |
doaj-dacb25b0d1d4449685db6787ee4691f2 |
---|---|
record_format |
Article |
spelling |
doaj-dacb25b0d1d4449685db6787ee4691f22021-09-26T00:53:58ZengMDPI AGPathogens2076-08172021-08-01101077107710.3390/pathogens10091077Coagulation Status in Dogs Naturally Infected with <i>Angiostrongylus vasorum</i>Nadja E. Sigrist0Lucienne Tritten1Claudia Kümmerle-Fraune2Natalie Hofer-Inteeworn3Rahel Jud Schefer4Manuela Schnyder5Annette P. N. Kutter6Department for Small Animals, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandInstitute of Parasitology, University of Zurich, 8057 Zurich, SwitzerlandDepartment for Small Animals, Clinic for Small Animal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandDepartment for Small Animals, Clinic for Small Animal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandDepartment for Small Animals, Division of Emergency and Critical Care, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandInstitute of Parasitology, University of Zurich, 8057 Zurich, SwitzerlandDepartment for Clinical Diagnostics and Services, Section Anaesthesiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland<i>Angiostrongylus vasorum</i> infection has been associated with coagulopathies including hyperfibrinolysis. We compared coagulation status including thromboelastometry (ROTEM) parameters in dogs naturally infected with <i>A. vasorum</i> versus healthy dogs to determine clinicopathological parameters associated with bleeding, hypocoagulopathy, and hyperfibrinolysis. Clinical signs, white blood cell count, platelet count, hematocrit, plasmatic coagulation tests (PT, aPTT, fibrinogen concentration), D-dimer, and ROTEM S parameters (Ex-tem, In-tem, Fib-tem, Ap-tem) were analysed and compared between bleeding, nonbleeding, and control dogs and between hypo- and normocoagulable animals. Clinical signs of bleeding were present in 6/9 (67%) hypocoagulable and 1/9 (11%) normocoagulable dogs. PT, fibrinogen concentration, and several ROTEM parameters were significantly different between hypocoagulable and normocoagulabe <i>A. vasorum</i> infected dogs. Hyperfibrinolysis was identified in 44% of infected dogs and was significantly more common in bleeding and hypocoagulable dogs. Hyperfibrinolysis was significantly associated with low MCFFib-tem but not with low fibrinogen concentration or increased D-dimers. CFTEx-tem > 248 swas 100% sensitive and 89% specific to predict hyperfibrinolysis. Hyperfibrinolysis, hypocoagulability and bleeding are common in <i>A. vasorum</i> infected dogs. Only Ex-tem and Fib-tem parameters and potentially PT were associated with bleeding or hypocoagulability. Ex-tem analysis enables detection of bleeding, hypocoagulability and hyperfibrinolysis within minutes.https://www.mdpi.com/2076-0817/10/9/1077angiostrongylosisbleeding diathesisfibrinogen |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nadja E. Sigrist Lucienne Tritten Claudia Kümmerle-Fraune Natalie Hofer-Inteeworn Rahel Jud Schefer Manuela Schnyder Annette P. N. Kutter |
spellingShingle |
Nadja E. Sigrist Lucienne Tritten Claudia Kümmerle-Fraune Natalie Hofer-Inteeworn Rahel Jud Schefer Manuela Schnyder Annette P. N. Kutter Coagulation Status in Dogs Naturally Infected with <i>Angiostrongylus vasorum</i> Pathogens angiostrongylosis bleeding diathesis fibrinogen |
author_facet |
Nadja E. Sigrist Lucienne Tritten Claudia Kümmerle-Fraune Natalie Hofer-Inteeworn Rahel Jud Schefer Manuela Schnyder Annette P. N. Kutter |
author_sort |
Nadja E. Sigrist |
title |
Coagulation Status in Dogs Naturally Infected with <i>Angiostrongylus vasorum</i> |
title_short |
Coagulation Status in Dogs Naturally Infected with <i>Angiostrongylus vasorum</i> |
title_full |
Coagulation Status in Dogs Naturally Infected with <i>Angiostrongylus vasorum</i> |
title_fullStr |
Coagulation Status in Dogs Naturally Infected with <i>Angiostrongylus vasorum</i> |
title_full_unstemmed |
Coagulation Status in Dogs Naturally Infected with <i>Angiostrongylus vasorum</i> |
title_sort |
coagulation status in dogs naturally infected with <i>angiostrongylus vasorum</i> |
publisher |
MDPI AG |
series |
Pathogens |
issn |
2076-0817 |
publishDate |
2021-08-01 |
description |
<i>Angiostrongylus vasorum</i> infection has been associated with coagulopathies including hyperfibrinolysis. We compared coagulation status including thromboelastometry (ROTEM) parameters in dogs naturally infected with <i>A. vasorum</i> versus healthy dogs to determine clinicopathological parameters associated with bleeding, hypocoagulopathy, and hyperfibrinolysis. Clinical signs, white blood cell count, platelet count, hematocrit, plasmatic coagulation tests (PT, aPTT, fibrinogen concentration), D-dimer, and ROTEM S parameters (Ex-tem, In-tem, Fib-tem, Ap-tem) were analysed and compared between bleeding, nonbleeding, and control dogs and between hypo- and normocoagulable animals. Clinical signs of bleeding were present in 6/9 (67%) hypocoagulable and 1/9 (11%) normocoagulable dogs. PT, fibrinogen concentration, and several ROTEM parameters were significantly different between hypocoagulable and normocoagulabe <i>A. vasorum</i> infected dogs. Hyperfibrinolysis was identified in 44% of infected dogs and was significantly more common in bleeding and hypocoagulable dogs. Hyperfibrinolysis was significantly associated with low MCFFib-tem but not with low fibrinogen concentration or increased D-dimers. CFTEx-tem > 248 swas 100% sensitive and 89% specific to predict hyperfibrinolysis. Hyperfibrinolysis, hypocoagulability and bleeding are common in <i>A. vasorum</i> infected dogs. Only Ex-tem and Fib-tem parameters and potentially PT were associated with bleeding or hypocoagulability. Ex-tem analysis enables detection of bleeding, hypocoagulability and hyperfibrinolysis within minutes. |
topic |
angiostrongylosis bleeding diathesis fibrinogen |
url |
https://www.mdpi.com/2076-0817/10/9/1077 |
work_keys_str_mv |
AT nadjaesigrist coagulationstatusindogsnaturallyinfectedwithiangiostrongylusvasorumi AT luciennetritten coagulationstatusindogsnaturallyinfectedwithiangiostrongylusvasorumi AT claudiakummerlefraune coagulationstatusindogsnaturallyinfectedwithiangiostrongylusvasorumi AT nataliehoferinteeworn coagulationstatusindogsnaturallyinfectedwithiangiostrongylusvasorumi AT raheljudschefer coagulationstatusindogsnaturallyinfectedwithiangiostrongylusvasorumi AT manuelaschnyder coagulationstatusindogsnaturallyinfectedwithiangiostrongylusvasorumi AT annettepnkutter coagulationstatusindogsnaturallyinfectedwithiangiostrongylusvasorumi |
_version_ |
1716869662059266048 |