Association of MTHFR C677T and A1298C gene polymorphisms with methotrexate efficiency and toxicity in Algerian rheumatoid arthritis patients

Association of MTHFR C677T and A1298C gene polymorphisms with methotrexate efficiency and toxicity in Algerian rheumatoid arthritis patients

Methotrexate (MTX) is the most used drug in rheumatoid arthritis (RA) treatment. However, it shows variability in clinical response, which is explained by an association with genetic polymorphisms. This study aimed to elucidate the role of the two gene polymorphism C677T and A1298C of the methylenet...

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Bibliographic Details
Main Authors:	Lilya M. Berkani, Fadia Rahal, Ines Allam, Soraya Mouaki Benani, Aïcha Laadjouz, Reda Djidjik
Format:	Article
Language:	English
Published:	Elsevier 2017-11-01
Series:	Heliyon
Subjects:	Genetics Clinical genetics Internal medicine Health sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844017315153

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