Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells
Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone. ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs). SLCs are spindle-shaped cells that lack steroidogenic cell markers, including luteinizing hormone (LH) receptor...
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doaj-dad1a2c7e7204981952b1d6bd59fb40e2020-11-24T21:29:10ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-06-01810.3389/fphys.2017.00430258582Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig CellsLeping YeXiaoheng LiLinxi LiHaolin ChenRen-Shan GeAdult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone. ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs). SLCs are spindle-shaped cells that lack steroidogenic cell markers, including luteinizing hormone (LH) receptor and 3β-hydroxysteroid dehydrogenase. The commitment of SLCs into the progenitor Leydig cells (PLCs), the first stage in the lineage, requires growth factors, including Dessert Hedgehog (DHH) and platelet-derived growth factor-AA. PLCs are still spindle-shaped, but become steroidogenic and produce mainly androsterone. The next transition in the lineage is from PLC to the immature Leydig cell (ILC). This transition requires LH, DHH, and androgen. ILCs are ovoid cells that are competent for producing a different form of androgen, androstanediol. The final stage in the developmental lineage is ALC. The transition to ALC involves the reduced expression of 5α-reductase 1, a step that is necessary to make the cells to produce testosterone as the final product. The transitions along the Leydig cell lineage are associated with the progressive down-regulation of the proliferative activity, and the up-regulation of steroidogenic capacity, with each step requiring unique regulatory signaling.http://journal.frontiersin.org/article/10.3389/fphys.2017.00430/fullLeydig cellstestosteronedevelopmentsteroidogenic factor 1Desert Hedgehog |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Leping Ye Xiaoheng Li Linxi Li Haolin Chen Ren-Shan Ge |
spellingShingle |
Leping Ye Xiaoheng Li Linxi Li Haolin Chen Ren-Shan Ge Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells Frontiers in Physiology Leydig cells testosterone development steroidogenic factor 1 Desert Hedgehog |
author_facet |
Leping Ye Xiaoheng Li Linxi Li Haolin Chen Ren-Shan Ge |
author_sort |
Leping Ye |
title |
Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells |
title_short |
Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells |
title_full |
Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells |
title_fullStr |
Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells |
title_full_unstemmed |
Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells |
title_sort |
insights into the development of the adult leydig cell lineage from stem leydig cells |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2017-06-01 |
description |
Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone. ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs). SLCs are spindle-shaped cells that lack steroidogenic cell markers, including luteinizing hormone (LH) receptor and 3β-hydroxysteroid dehydrogenase. The commitment of SLCs into the progenitor Leydig cells (PLCs), the first stage in the lineage, requires growth factors, including Dessert Hedgehog (DHH) and platelet-derived growth factor-AA. PLCs are still spindle-shaped, but become steroidogenic and produce mainly androsterone. The next transition in the lineage is from PLC to the immature Leydig cell (ILC). This transition requires LH, DHH, and androgen. ILCs are ovoid cells that are competent for producing a different form of androgen, androstanediol. The final stage in the developmental lineage is ALC. The transition to ALC involves the reduced expression of 5α-reductase 1, a step that is necessary to make the cells to produce testosterone as the final product. The transitions along the Leydig cell lineage are associated with the progressive down-regulation of the proliferative activity, and the up-regulation of steroidogenic capacity, with each step requiring unique regulatory signaling. |
topic |
Leydig cells testosterone development steroidogenic factor 1 Desert Hedgehog |
url |
http://journal.frontiersin.org/article/10.3389/fphys.2017.00430/full |
work_keys_str_mv |
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