Comparison of the selenium dioxide and green tea extract on serum lipids level in rats

• Main Authors: GA Naderi, S Bakhtiari, A Almasi, S Javanbakhti, R Mookhah
• Format: Article
• Language: English
• Published: Institue of Medicinal Plants, ACECR 2006-03-01
• Series: Journal of Medicinal Plants
• Subjects: catechin; epigallocatechin-3-gallate; anti-oxidant; high fat diet
• Online Access: http://jmp.ir/article-1-676-en.html

Background: Compounds with anti-oxidant properties cause reduction of lipid peroxidation, LDL and increment of HDL serumic level. Catechins are the major component of the green tea and have strong anti-oxidant properties. One of these catechins is epigallocatechin-3-gallate (EGCG). Selenium is the cofactor of glutathione peroxidase enzyme and has anti-oxidant properties. Objective: The purpose of this investigation was the comparison of EGCG and SiO2 on rats serumic lipid level. Methods: In this investigation 20 Wistar rats were selected and were fed a diet high fat for 4 weeks. Then blood samples from rats were prepared and serumic level of triglyceride, cholesterol and HDL-cholesterol were measured by kits. 15 rats of these were selected and were randomly divided to three experimental groups consisting of 5 animals each. All groups were fed with the same high fat diet. One group were control, another group was injected with EGCG and the other group was injected with SiO2. Blood samples from rats were prepared again and sermic level of triglyceride, cholesterol and HDL-cholesterol were measured. Results: EGCG has stronger reductive effects on serumic cholesterol than SiO2 and it is EGCG was decreased serumic level of HDL-cholesterol more than SiO2. Also EGCG was decreased serumic level of cholesterol and triglyceride more than SiO2.