Lack of Association between Helicobacter pylori Infection and Various Markers of Systemic Inflammation in Asymptomatic Adults
Background/Aims: Helicobacter pylori (H. pylori) infection has been known to cause various extra-gastric diseases, which may be mediated by an increase in systemic inflammation. Thus, we examined the association between H. pylori infection and various markers of systemic inflammation in a large samp...
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2018-07-01
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doaj-dad4b7bbc05a4478aca03d5d140c750b2020-11-25T02:32:02ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922018-07-01721212710.4166/kjg.2018.72.1.21kjg.2018.72.1.21Lack of Association between Helicobacter pylori Infection and Various Markers of Systemic Inflammation in Asymptomatic AdultsTae Jun Kim0Jeung Hui Pyo1Hyuk Lee2Sun-Young Baek3Soo Hyun Ahn4Yang Won Min5Byung-Hoon Min6Jun Haeng Lee7Hee Jung Son8Poong-Lyul Rhee9Jae J Kim10Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaCenter for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaStatistics and Data Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaStatistics and Data Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaBackground/Aims: Helicobacter pylori (H. pylori) infection has been known to cause various extra-gastric diseases, which may be mediated by an increase in systemic inflammation. Thus, we examined the association between H. pylori infection and various markers of systemic inflammation in a large sample of asymptomatic adults. Methods: Cross-sectional data were obtained from 17,028 adults who completed routine health check-ups. H. pylori infection status was determined using a serum immunoglobulin G test, and systemic inflammation was assessed using the C-reactive protein (CRP) levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). Results: Multiple linear regression model-adjusted for potential confounders-revealed that H. pylori infection was not associated with CRP levels (coefficient: -0.012, 95% confidence interval [CI]: -0.037, 0.012, p=0.319), NLR (coefficient: 0.055, 95% CI: -0.027, 0.138, p=0.192), or PLR (coefficient: 1.798, 95% CI: -1.979, 5.574, p=0.351). In a multivariable logistic regression model, H. pylori infection was not associated with the risk of CRP levels being elevated to ≥0.1 mg/dL (odds ratio: 0.96, 95% CI: 0.81, 1.08) or ≥0.3 mg/dL(odds ratio: 1.02, 95% CI: 0.84, 1.19). In the multivariable model, CRP levels elevated to ≥0.1 mg/dL were significantly associated with body mass index, current smoking status, hypertension, and diabetes mellitus. Regular exercise and high-density lipoprotein cholesterol were factors that minimized the elevation of CRP levels. Conclusions: Chronic infection with H. pylori was not associated with various inflammatory markers. Further investigation is needed to clarify the interaction between H. pylori infection, systemic inflammation, and extra-gastric disease.http://www.kjg.or.kr/journal/view.html?doi=10.4166/kjg.2018.72.1.21Helicobacter pyloriInflammationC-reactive protein |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tae Jun Kim Jeung Hui Pyo Hyuk Lee Sun-Young Baek Soo Hyun Ahn Yang Won Min Byung-Hoon Min Jun Haeng Lee Hee Jung Son Poong-Lyul Rhee Jae J Kim |
spellingShingle |
Tae Jun Kim Jeung Hui Pyo Hyuk Lee Sun-Young Baek Soo Hyun Ahn Yang Won Min Byung-Hoon Min Jun Haeng Lee Hee Jung Son Poong-Lyul Rhee Jae J Kim Lack of Association between Helicobacter pylori Infection and Various Markers of Systemic Inflammation in Asymptomatic Adults The Korean Journal of Gastroenterology Helicobacter pylori Inflammation C-reactive protein |
author_facet |
Tae Jun Kim Jeung Hui Pyo Hyuk Lee Sun-Young Baek Soo Hyun Ahn Yang Won Min Byung-Hoon Min Jun Haeng Lee Hee Jung Son Poong-Lyul Rhee Jae J Kim |
author_sort |
Tae Jun Kim |
title |
Lack of Association between Helicobacter pylori Infection and Various Markers of Systemic Inflammation in Asymptomatic Adults |
title_short |
Lack of Association between Helicobacter pylori Infection and Various Markers of Systemic Inflammation in Asymptomatic Adults |
title_full |
Lack of Association between Helicobacter pylori Infection and Various Markers of Systemic Inflammation in Asymptomatic Adults |
title_fullStr |
Lack of Association between Helicobacter pylori Infection and Various Markers of Systemic Inflammation in Asymptomatic Adults |
title_full_unstemmed |
Lack of Association between Helicobacter pylori Infection and Various Markers of Systemic Inflammation in Asymptomatic Adults |
title_sort |
lack of association between helicobacter pylori infection and various markers of systemic inflammation in asymptomatic adults |
publisher |
Jin Publishing & Printing Co. |
series |
The Korean Journal of Gastroenterology |
issn |
1598-9992 |
publishDate |
2018-07-01 |
description |
Background/Aims: Helicobacter pylori (H. pylori) infection has been known to cause various extra-gastric diseases, which may be mediated by an increase in systemic inflammation. Thus, we examined the association between H. pylori infection and various markers of systemic inflammation in a large sample of asymptomatic adults.
Methods: Cross-sectional data were obtained from 17,028 adults who completed routine health check-ups. H. pylori infection status was determined using a serum immunoglobulin G test, and systemic inflammation was assessed using the C-reactive protein (CRP) levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR).
Results: Multiple linear regression model-adjusted for potential confounders-revealed that H. pylori infection was not associated with CRP levels (coefficient: -0.012, 95% confidence interval [CI]: -0.037, 0.012, p=0.319), NLR (coefficient: 0.055, 95% CI: -0.027, 0.138, p=0.192), or PLR (coefficient: 1.798, 95% CI: -1.979, 5.574, p=0.351). In a multivariable logistic regression model, H. pylori infection was not associated with the risk of CRP levels being elevated to ≥0.1 mg/dL (odds ratio: 0.96, 95% CI: 0.81, 1.08) or ≥0.3 mg/dL(odds ratio: 1.02, 95% CI: 0.84, 1.19). In the multivariable model, CRP levels elevated to ≥0.1 mg/dL were significantly associated with body mass index, current smoking status, hypertension, and diabetes mellitus. Regular exercise and high-density lipoprotein cholesterol were factors that minimized the elevation of CRP levels.
Conclusions: Chronic infection with H. pylori was not associated with various inflammatory markers. Further investigation is needed to clarify the interaction between H. pylori infection, systemic inflammation, and extra-gastric disease. |
topic |
Helicobacter pylori Inflammation C-reactive protein |
url |
http://www.kjg.or.kr/journal/view.html?doi=10.4166/kjg.2018.72.1.21 |
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