Association of reduced inner retinal thicknesses with chronic kidney disease
Abstract Background Tissue derived biomarkers may offer utility as indicators of accumulated damage. Reduced thickness of retinal neuronal tissue and the vascular choroid have previously been associated with vascular damage and diabetes. We evaluated associations between retinal thickness, retinal m...
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doaj-dadefa99d9ae4d9085fbfa23e67713352021-01-31T16:37:24ZengBMCBMC Nephrology1471-23692020-01-0121111210.1186/s12882-019-1679-1Association of reduced inner retinal thicknesses with chronic kidney diseaseEuan N. Paterson0Meera L. Ravindran1Kayleigh Griffiths2Claire A. Le Velly3Chris C. Cardwell4Rachel V. McCarter5Patrick Nicol6Jay K. Chhablani7Mohammed Abdul Rasheed8Kiran Kumar Vupparaboina9Thomas J. MacGillivray10Mark Harbinson11Alexander P. Maxwell12Ruth E. Hogg13Gareth J. McKay14Centre for Public Health, Queen’s University BelfastCentre for Public Health, Queen’s University BelfastCentre for Public Health, Queen’s University BelfastCentre for Public Health, Queen’s University BelfastCentre for Public Health, Queen’s University BelfastCentre for Public Health, Queen’s University BelfastCentre for Public Health, Queen’s University BelfastDepartment of Ophthalmology, University of Pittsburgh Medical CenterL.V. Prasad Eye InstituteL.V. Prasad Eye InstituteCentre for Clinical Brain Sciences, University of EdinburghCentre for Medical Education, Queen’s University BelfastCentre for Public Health, Queen’s University BelfastCentre for Public Health, Queen’s University BelfastCentre for Public Health, Queen’s University BelfastAbstract Background Tissue derived biomarkers may offer utility as indicators of accumulated damage. Reduced thickness of retinal neuronal tissue and the vascular choroid have previously been associated with vascular damage and diabetes. We evaluated associations between retinal thickness, retinal microvascular and choroidal measures, and renal function in a population with a high burden of comorbidity. Methods Participants were recruited from nuclear cardiology or renal medicine clinics. Retinal and choroidal thickness were measured from spectral-domain optical coherence tomograms. Retinal microvascular parameters were assessed from digital fundus photographs using a semi-automated software package. Main Outcome Measure: Chronic kidney disease (CKD) categorised as: CKD stages 1–2, eGFR ≥60 ml/min/1.73m2; CKD stage 3, eGFR 30–59 ml/min/1.73m2, and CKD stages 4–5, eGFR ≤29 ml/min/1.73m2. Results Participants (n = 241) had a mean age of 65 years and a mean eGFR of 66.9 ml/min/1.73m2. Thirty–nine % of the cohort had diabetes and 27% were using diuretics. Thinning of the inner retina and changes to its microvascular blood supply were associated with lower eGFR and CKD stages 4 and 5, while no associations were found between the outer retinal layers or their choroidal blood supply and CKD of any stage. These associations remained following adjustment for age, mean arterial blood pressure, diabetes status, low-density lipoprotein, body mass index, and sex. Conclusions Inner retinal thinning and retinal microvascular variation is associated with advanced CKD (stages 4 & 5) independent of important confounding factors, but not with earlier stage CKD (stage 3) and, therefore, its utility as a biomarker for early CKD is not supported in this study.https://doi.org/10.1186/s12882-019-1679-1Renal functionChronic kidney diseaseRetinaRetinal microvasculatureChoroidRetinal thickness |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Euan N. Paterson Meera L. Ravindran Kayleigh Griffiths Claire A. Le Velly Chris C. Cardwell Rachel V. McCarter Patrick Nicol Jay K. Chhablani Mohammed Abdul Rasheed Kiran Kumar Vupparaboina Thomas J. MacGillivray Mark Harbinson Alexander P. Maxwell Ruth E. Hogg Gareth J. McKay |
spellingShingle |
Euan N. Paterson Meera L. Ravindran Kayleigh Griffiths Claire A. Le Velly Chris C. Cardwell Rachel V. McCarter Patrick Nicol Jay K. Chhablani Mohammed Abdul Rasheed Kiran Kumar Vupparaboina Thomas J. MacGillivray Mark Harbinson Alexander P. Maxwell Ruth E. Hogg Gareth J. McKay Association of reduced inner retinal thicknesses with chronic kidney disease BMC Nephrology Renal function Chronic kidney disease Retina Retinal microvasculature Choroid Retinal thickness |
author_facet |
Euan N. Paterson Meera L. Ravindran Kayleigh Griffiths Claire A. Le Velly Chris C. Cardwell Rachel V. McCarter Patrick Nicol Jay K. Chhablani Mohammed Abdul Rasheed Kiran Kumar Vupparaboina Thomas J. MacGillivray Mark Harbinson Alexander P. Maxwell Ruth E. Hogg Gareth J. McKay |
author_sort |
Euan N. Paterson |
title |
Association of reduced inner retinal thicknesses with chronic kidney disease |
title_short |
Association of reduced inner retinal thicknesses with chronic kidney disease |
title_full |
Association of reduced inner retinal thicknesses with chronic kidney disease |
title_fullStr |
Association of reduced inner retinal thicknesses with chronic kidney disease |
title_full_unstemmed |
Association of reduced inner retinal thicknesses with chronic kidney disease |
title_sort |
association of reduced inner retinal thicknesses with chronic kidney disease |
publisher |
BMC |
series |
BMC Nephrology |
issn |
1471-2369 |
publishDate |
2020-01-01 |
description |
Abstract Background Tissue derived biomarkers may offer utility as indicators of accumulated damage. Reduced thickness of retinal neuronal tissue and the vascular choroid have previously been associated with vascular damage and diabetes. We evaluated associations between retinal thickness, retinal microvascular and choroidal measures, and renal function in a population with a high burden of comorbidity. Methods Participants were recruited from nuclear cardiology or renal medicine clinics. Retinal and choroidal thickness were measured from spectral-domain optical coherence tomograms. Retinal microvascular parameters were assessed from digital fundus photographs using a semi-automated software package. Main Outcome Measure: Chronic kidney disease (CKD) categorised as: CKD stages 1–2, eGFR ≥60 ml/min/1.73m2; CKD stage 3, eGFR 30–59 ml/min/1.73m2, and CKD stages 4–5, eGFR ≤29 ml/min/1.73m2. Results Participants (n = 241) had a mean age of 65 years and a mean eGFR of 66.9 ml/min/1.73m2. Thirty–nine % of the cohort had diabetes and 27% were using diuretics. Thinning of the inner retina and changes to its microvascular blood supply were associated with lower eGFR and CKD stages 4 and 5, while no associations were found between the outer retinal layers or their choroidal blood supply and CKD of any stage. These associations remained following adjustment for age, mean arterial blood pressure, diabetes status, low-density lipoprotein, body mass index, and sex. Conclusions Inner retinal thinning and retinal microvascular variation is associated with advanced CKD (stages 4 & 5) independent of important confounding factors, but not with earlier stage CKD (stage 3) and, therefore, its utility as a biomarker for early CKD is not supported in this study. |
topic |
Renal function Chronic kidney disease Retina Retinal microvasculature Choroid Retinal thickness |
url |
https://doi.org/10.1186/s12882-019-1679-1 |
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