Theoretical Explorations Generate New Hypotheses About the Role of the Cartilage Endplate in Early Intervertebral Disk Degeneration

Theoretical Explorations Generate New Hypotheses About the Role of the Cartilage Endplate in Early Intervertebral Disk Degeneration

Altered cell nutrition in the intervertebral disk (IVD) is considered a main cause for disk degeneration (DD). The cartilage endplate (CEP) provides a major path for the diffusion of nutrients from the peripheral vasculature to the IVD nucleus pulposus (NP). In DD, sclerosis of the adjacent bony end...

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Bibliographic Details
Main Authors: Carlos Ruiz Wills, Baptiste Foata, Miguel Á. González Ballester, Jaro Karppinen, Jérôme Noailly
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Physiology
Subjects:
intervertebral disk degeneration
cartilage endplates
composition-dependent tissue permeability
finite elements simulations
disc cell nutrition
indirect mechanotransduction
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01210/full

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