Pharmacological treatment with cabergoline in three cats with acromegaly
Abstract Anamnesis: Three cats diagnosed with diabetes mellitus (DM) were referred for examination due to the presence of insulin resistance signs, which included polyuria, polydipsia, polyphagia and high fructosamine levels, even with insulin glargine doses greater than 2 U/Kg/application. Clinic...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Universidad de Antioquia
|
Series: | Revista Colombiana de Ciencias Pecuarias |
Subjects: | |
Online Access: | http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-06902017000400316&lng=en&tlng=en |
id |
doaj-daedf84d70294def967385bcdf8924f4 |
---|---|
record_format |
Article |
spelling |
doaj-daedf84d70294def967385bcdf8924f42020-11-25T01:02:20ZengUniversidad de AntioquiaRevista Colombiana de Ciencias Pecuarias0120-069030431632110.17533/udea.rccp.v30n4a07S0120-06902017000400316Pharmacological treatment with cabergoline in three cats with acromegalyElber A Soler-AriasJorge D GarcíaVíctor A CastilloAbstract Anamnesis: Three cats diagnosed with diabetes mellitus (DM) were referred for examination due to the presence of insulin resistance signs, which included polyuria, polydipsia, polyphagia and high fructosamine levels, even with insulin glargine doses greater than 2 U/Kg/application. Clinical and laboratory findings: All patients had enlarged facial features along with increased interdental space. The biochemical tests revealed high IGF-1 concentrations. The magnetic resonance imaging displayed enlarged pituitary gland in one of the cats and images compatible with a pituitary macroadenoma in the other two. Acromegaly was the final diagnosis. Treatment approach: Oral cabergoline at 10 µg/Kg every 48 h was administered. Conclusion: The treatment with cabergoline successfully decreased IGF-1 concentrations and all insulin resistance signs, and it enhanced glycemic control for the DM in the three cats. Our results suggest cabergoline could be used for the treatment of acromegaly in cats.http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-06902017000400316&lng=en&tlng=endiabetesdopaminergic agonistgrowth hormonehypersomatotropismIGF-1insulin resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elber A Soler-Arias Jorge D García Víctor A Castillo |
spellingShingle |
Elber A Soler-Arias Jorge D García Víctor A Castillo Pharmacological treatment with cabergoline in three cats with acromegaly Revista Colombiana de Ciencias Pecuarias diabetes dopaminergic agonist growth hormone hypersomatotropism IGF-1 insulin resistance |
author_facet |
Elber A Soler-Arias Jorge D García Víctor A Castillo |
author_sort |
Elber A Soler-Arias |
title |
Pharmacological treatment with cabergoline in three cats with acromegaly |
title_short |
Pharmacological treatment with cabergoline in three cats with acromegaly |
title_full |
Pharmacological treatment with cabergoline in three cats with acromegaly |
title_fullStr |
Pharmacological treatment with cabergoline in three cats with acromegaly |
title_full_unstemmed |
Pharmacological treatment with cabergoline in three cats with acromegaly |
title_sort |
pharmacological treatment with cabergoline in three cats with acromegaly |
publisher |
Universidad de Antioquia |
series |
Revista Colombiana de Ciencias Pecuarias |
issn |
0120-0690 |
description |
Abstract Anamnesis: Three cats diagnosed with diabetes mellitus (DM) were referred for examination due to the presence of insulin resistance signs, which included polyuria, polydipsia, polyphagia and high fructosamine levels, even with insulin glargine doses greater than 2 U/Kg/application. Clinical and laboratory findings: All patients had enlarged facial features along with increased interdental space. The biochemical tests revealed high IGF-1 concentrations. The magnetic resonance imaging displayed enlarged pituitary gland in one of the cats and images compatible with a pituitary macroadenoma in the other two. Acromegaly was the final diagnosis. Treatment approach: Oral cabergoline at 10 µg/Kg every 48 h was administered. Conclusion: The treatment with cabergoline successfully decreased IGF-1 concentrations and all insulin resistance signs, and it enhanced glycemic control for the DM in the three cats. Our results suggest cabergoline could be used for the treatment of acromegaly in cats. |
topic |
diabetes dopaminergic agonist growth hormone hypersomatotropism IGF-1 insulin resistance |
url |
http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-06902017000400316&lng=en&tlng=en |
work_keys_str_mv |
AT elberasolerarias pharmacologicaltreatmentwithcabergolineinthreecatswithacromegaly AT jorgedgarcia pharmacologicaltreatmentwithcabergolineinthreecatswithacromegaly AT victoracastillo pharmacologicaltreatmentwithcabergolineinthreecatswithacromegaly |
_version_ |
1725205441210744832 |