Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier.

Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier.

Drug delivery into the brain is impeded by the blood-brain-barrier (BBB) that filters out the vast majority of drugs after systemic administration. In this work, we assessed the transport, uptake and cytotoxicity of promising drug nanocarriers, mesoporous silica nanoparticles (MSNs), in in vitro mod...

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Bibliographic Details
Main Authors: Habib Baghirov, Didem Karaman, Tapani Viitala, Alain Duchanoy, Yan-Ru Lou, Veronika Mamaeva, Evgeny Pryazhnikov, Leonard Khiroug, Catharina de Lange Davies, Cecilia Sahlgren, Jessica M Rosenholm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4993362?pdf=render

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http://europepmc.org/articles/PMC4993362?pdf=render

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