Role of androgen receptor splice variants in prostate cancer metastasis

Prostate cancer (PCa) is one of the most lethal cancers in western countries. Androgen receptor (AR) signaling pathway plays a key role in PCa progression. Despite the initial effectiveness of androgen deprivation therapy (ADT)for treatment of patients with advanced PCa, most of them will develop re...

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Main Authors: Jin Xu, Yun Qiu
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Asian Journal of Urology
Online Access:http://www.sciencedirect.com/science/article/pii/S2214388216300479
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spelling doaj-dafdf315defb4a33a86e13412c6c44242020-11-24T21:54:02ZengElsevierAsian Journal of Urology2214-38822016-10-0134177184Role of androgen receptor splice variants in prostate cancer metastasisJin Xu0Yun Qiu1Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USACorresponding author.; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USAProstate cancer (PCa) is one of the most lethal cancers in western countries. Androgen receptor (AR) signaling pathway plays a key role in PCa progression. Despite the initial effectiveness of androgen deprivation therapy (ADT)for treatment of patients with advanced PCa, most of them will develop resistance to ADT and progress to metastatic castration resistant prostate cancer (mCRPC). Constitutively transcriptional activated AR splice variants (AR-Vs) have emerged as critical players in the development and progression of mCRPC. Among AR-Vs identified to date, AR-V7 (a.k.a. AR3) is one of the most abundant and frequently found in both PCa cell lines and in human prostate tissues. Most of functional studies have been focused on AR-V7/AR3 and revealed its role in regulation of survival, growth, differentiation and migration in prostate cells. In this review, we will summarize our current understanding of regulation of expression and activity of AR-Vs in mCRPC. Keywords: Prostate cancer, Androgen receptor splicing variants, Metastatic castration resistant prostate cancerhttp://www.sciencedirect.com/science/article/pii/S2214388216300479
collection DOAJ
language English
format Article
sources DOAJ
author Jin Xu
Yun Qiu
spellingShingle Jin Xu
Yun Qiu
Role of androgen receptor splice variants in prostate cancer metastasis
Asian Journal of Urology
author_facet Jin Xu
Yun Qiu
author_sort Jin Xu
title Role of androgen receptor splice variants in prostate cancer metastasis
title_short Role of androgen receptor splice variants in prostate cancer metastasis
title_full Role of androgen receptor splice variants in prostate cancer metastasis
title_fullStr Role of androgen receptor splice variants in prostate cancer metastasis
title_full_unstemmed Role of androgen receptor splice variants in prostate cancer metastasis
title_sort role of androgen receptor splice variants in prostate cancer metastasis
publisher Elsevier
series Asian Journal of Urology
issn 2214-3882
publishDate 2016-10-01
description Prostate cancer (PCa) is one of the most lethal cancers in western countries. Androgen receptor (AR) signaling pathway plays a key role in PCa progression. Despite the initial effectiveness of androgen deprivation therapy (ADT)for treatment of patients with advanced PCa, most of them will develop resistance to ADT and progress to metastatic castration resistant prostate cancer (mCRPC). Constitutively transcriptional activated AR splice variants (AR-Vs) have emerged as critical players in the development and progression of mCRPC. Among AR-Vs identified to date, AR-V7 (a.k.a. AR3) is one of the most abundant and frequently found in both PCa cell lines and in human prostate tissues. Most of functional studies have been focused on AR-V7/AR3 and revealed its role in regulation of survival, growth, differentiation and migration in prostate cells. In this review, we will summarize our current understanding of regulation of expression and activity of AR-Vs in mCRPC. Keywords: Prostate cancer, Androgen receptor splicing variants, Metastatic castration resistant prostate cancer
url http://www.sciencedirect.com/science/article/pii/S2214388216300479
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AT yunqiu roleofandrogenreceptorsplicevariantsinprostatecancermetastasis
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