Effects of Length and Loop Composition on Structural Diversity and Similarity of (G<sub>3</sub>TG<sub>3</sub>N<sub>m</sub>G<sub>3</sub>TG<sub>3</sub>) G-Quadruplexes

Effects of Length and Loop Composition on Structural Diversity and Similarity of (G<sub>3</sub>TG<sub>3</sub>N<sub>m</sub>G<sub>3</sub>TG<sub>3</sub>) G-Quadruplexes

A G-rich sequence containing three loops to connect four G-tracts with each ≥2 guanines can possibly form G-quadruplex structures. Given that all G-quadruplex structures comprise the stacking of G-quartets, the loop sequence plays a major role on their folding topology and thermal stability. Here ci...

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Bibliographic Details
Main Authors: Jie Li, I-Te Chu, Ting-An Yeh, De-Yu Chen, Chiung-Lin Wang, Ta-Chau Chang
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
G-quadruplex
structural diversity
structural similarity
loop length
base composition
flanking nucleotide
Online Access:https://www.mdpi.com/1420-3049/25/8/1779

Internet

https://www.mdpi.com/1420-3049/25/8/1779

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