Morbidity and mortality in preterm infants less than 29 weeks of gestational age
Background: Preterm birth is certainly a public health problem. Aside from being an important cause of mortality, prematurity increases the risk of serious lifetime disabilities. Objective: To assess the overall survival, causes of death and neonatal morbidities associated with prematurity of newbo...
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doaj-db0339c031954e54b5e1e2a07749b3082020-11-25T03:33:38ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922019-02-0181e080110e08011010.7363/080110517Morbidity and mortality in preterm infants less than 29 weeks of gestational ageBeatriz Riquito Marques0Ana Clara Dinis1Gustavo Rocha2Filipa Flôr-de-Lima3Ana Cristina Matos4Carla Henriques5Hercília Guimarães6Faculty of Medicine, University of Porto, Porto, PortugalFaculty of Medicine, University of Porto, Porto, PortugalFaculty of Medicine, University of Porto, Porto, Portugal; Neonatal Intensive Care Unit, Centro Hospitalar São João, Porto, PortugalFaculty of Medicine, University of Porto, Porto, Portugal; Neonatal Intensive Care Unit, Centro Hospitalar São João, Porto, PortugalSchool of Technology and Management, Polytechnic Institute of Viseu, Viseu, Portugal; Center for the Study of Education, Technologies and Health, Viseu, PortugalSchool of Technology and Management, Polytechnic Institute of Viseu, Viseu, Portugal; Center for Mathematics, University of Coimbra, Coimbra, PortugalFaculty of Medicine, University of Porto, Porto, Portugal; Neonatal Intensive Care Unit, Centro Hospitalar São João, Porto, Portugal; Cardiovascular R&D Unit of Faculty of Medicine, University of Porto, Porto, PortugalBackground: Preterm birth is certainly a public health problem. Aside from being an important cause of mortality, prematurity increases the risk of serious lifetime disabilities. Objective: To assess the overall survival, causes of death and neonatal morbidities associated with prematurity of newborns less than 29 weeks of gestational age (GA). Methods: Retrospective study including all preterm infants less than 29 weeks of GA admitted to the level III Neonatal Intensive Care Unit (NICU) at Centro Hospital São João in Porto, Portugal, between January 1st, 2005 and December 31st, 2016. Newborns were grouped into three groups according to their GA: G23+0-24+6, G25+0-26+6, G27+0-28+6. Results: In this 12-year-period, 160 preterm neonates less than 29 weeks of GA admitted to this NICU met our inclusion criteria. Overall deaths were 60 (37.5%), variating between 25 (92.6%) in the G23+0-24+6, 23 (46%) in the G25+0-26+6 and 12 (14.5%) in the G27+0-28+6. The leading causes of death were intraventricular hemorrhage (IVH) and sepsis. Early neonatal mortality was 20.6%. Among survivors, 41% had bronchopulmonary dysplasia (BPD), 69% developed late sepsis, 56% retinopathy of prematurity (ROP), 44% IVH and 10% cystic periventricular leukomalacia (cPVL). Conclusions: Mortality rates in this preterm group were high in spite of all the technological and scientific advances. Pulmonary conditions (respiratory distress syndrome and BPD), sepsis and neurologic outcomes (ROP, IVH and cPVL) were still major causes of morbidity. In line with other series, the limit of viability in this cohort of preterm infants is 25 weeks of GA. Prenatal, perinatal and postnatal care still all have a long road ahead, especially when it comes to these “gray zone” newborns.https://www.jpnim.com/index.php/jpnim/article/view/617preterm infantmortalitymorbiditylimit of viabilityneonatal intensive care unitbronchopulmonary dysplasia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Beatriz Riquito Marques Ana Clara Dinis Gustavo Rocha Filipa Flôr-de-Lima Ana Cristina Matos Carla Henriques Hercília Guimarães |
spellingShingle |
Beatriz Riquito Marques Ana Clara Dinis Gustavo Rocha Filipa Flôr-de-Lima Ana Cristina Matos Carla Henriques Hercília Guimarães Morbidity and mortality in preterm infants less than 29 weeks of gestational age Journal of Pediatric and Neonatal Individualized Medicine preterm infant mortality morbidity limit of viability neonatal intensive care unit bronchopulmonary dysplasia |
author_facet |
Beatriz Riquito Marques Ana Clara Dinis Gustavo Rocha Filipa Flôr-de-Lima Ana Cristina Matos Carla Henriques Hercília Guimarães |
author_sort |
Beatriz Riquito Marques |
title |
Morbidity and mortality in preterm infants less than 29 weeks of gestational age |
title_short |
Morbidity and mortality in preterm infants less than 29 weeks of gestational age |
title_full |
Morbidity and mortality in preterm infants less than 29 weeks of gestational age |
title_fullStr |
Morbidity and mortality in preterm infants less than 29 weeks of gestational age |
title_full_unstemmed |
Morbidity and mortality in preterm infants less than 29 weeks of gestational age |
title_sort |
morbidity and mortality in preterm infants less than 29 weeks of gestational age |
publisher |
Hygeia Press di Corridori Marinella |
series |
Journal of Pediatric and Neonatal Individualized Medicine |
issn |
2281-0692 |
publishDate |
2019-02-01 |
description |
Background: Preterm birth is certainly a public health problem. Aside from being an important cause of mortality, prematurity increases the risk of serious lifetime disabilities.
Objective: To assess the overall survival, causes of death and neonatal morbidities associated with prematurity of newborns less than 29 weeks of gestational age (GA).
Methods: Retrospective study including all preterm infants less than 29 weeks of GA admitted to the level III Neonatal Intensive Care Unit (NICU) at Centro Hospital São João in Porto, Portugal, between January 1st, 2005 and December 31st, 2016. Newborns were grouped into three groups according to their GA: G23+0-24+6, G25+0-26+6, G27+0-28+6.
Results: In this 12-year-period, 160 preterm neonates less than 29 weeks of GA admitted to this NICU met our inclusion criteria. Overall deaths were 60 (37.5%), variating between 25 (92.6%) in the G23+0-24+6, 23 (46%) in the G25+0-26+6 and 12 (14.5%) in the G27+0-28+6. The leading causes of death were intraventricular hemorrhage (IVH) and sepsis. Early neonatal mortality was 20.6%. Among survivors, 41% had bronchopulmonary dysplasia (BPD), 69% developed late sepsis, 56% retinopathy of prematurity (ROP), 44% IVH and 10% cystic periventricular leukomalacia (cPVL).
Conclusions: Mortality rates in this preterm group were high in spite of all the technological and scientific advances. Pulmonary conditions (respiratory distress syndrome and BPD), sepsis and neurologic outcomes (ROP, IVH and cPVL) were still major causes of morbidity. In line with other series, the limit of viability in this cohort of preterm infants is 25 weeks of GA. Prenatal, perinatal and postnatal care still all have a long road ahead, especially when it comes to these “gray zone” newborns. |
topic |
preterm infant mortality morbidity limit of viability neonatal intensive care unit bronchopulmonary dysplasia |
url |
https://www.jpnim.com/index.php/jpnim/article/view/617 |
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