Modulation of Ion Transport Across Plant Membranes by Polyamines: Understanding Specific Modes of Action Under Stress
This work critically discusses the direct and indirect effects of natural polyamines and their catabolites such as reactive oxygen species and γ-aminobutyric acid on the activity of key plant ion-transporting proteins such as plasma membrane H+ and Ca2+ ATPases and K+-selective and cation channels i...
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doaj-db065657a14c4a34af3b43d87b92f6522021-01-26T05:33:28ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2021-01-011110.3389/fpls.2020.616077616077Modulation of Ion Transport Across Plant Membranes by Polyamines: Understanding Specific Modes of Action Under StressIgor Pottosin0Igor Pottosin1Miguel Olivas-Aguirre2Oxana Dobrovinskaya3Isaac Zepeda-Jazo4Sergey Shabala5Sergey Shabala6International Research Centre for Environmental Membrane Biology, Foshan University, Foshan, ChinaBiomedical Center, University of Colima, Colima, MexicoBiomedical Center, University of Colima, Colima, MexicoBiomedical Center, University of Colima, Colima, MexicoFood Genomics Department, Universidad de La Ciénega del Estado de Michoacán de Ocampo, Sahuayo, MexicoInternational Research Centre for Environmental Membrane Biology, Foshan University, Foshan, ChinaTasmanian Institute for Agriculture, College of Science and Engineering, University of Tasmania, Hobart, TAS, AustraliaThis work critically discusses the direct and indirect effects of natural polyamines and their catabolites such as reactive oxygen species and γ-aminobutyric acid on the activity of key plant ion-transporting proteins such as plasma membrane H+ and Ca2+ ATPases and K+-selective and cation channels in the plasma membrane and tonoplast, in the context of their involvement in stress responses. Docking analysis predicts a distinct binding for putrescine and longer polyamines within the pore of the vacuolar TPC1/SV channel, one of the key determinants of the cell ionic homeostasis and signaling under stress conditions, and an additional site for spermine, which overlaps with the cytosolic regulatory Ca2+-binding site. Several unresolved problems are summarized, including the correct estimates of the subcellular levels of polyamines and their catabolites, their unexplored effects on nucleotide-gated and glutamate receptor channels of cell membranes and Ca2+-permeable and K+-selective channels in the membranes of plant mitochondria and chloroplasts, and pleiotropic mechanisms of polyamines’ action on H+ and Ca2+ pumps.https://www.frontiersin.org/articles/10.3389/fpls.2020.616077/fullabiotic stressCa2+ ATPaseH+-ATPaseion channelorganellepolyamines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Igor Pottosin Igor Pottosin Miguel Olivas-Aguirre Oxana Dobrovinskaya Isaac Zepeda-Jazo Sergey Shabala Sergey Shabala |
spellingShingle |
Igor Pottosin Igor Pottosin Miguel Olivas-Aguirre Oxana Dobrovinskaya Isaac Zepeda-Jazo Sergey Shabala Sergey Shabala Modulation of Ion Transport Across Plant Membranes by Polyamines: Understanding Specific Modes of Action Under Stress Frontiers in Plant Science abiotic stress Ca2+ ATPase H+-ATPase ion channel organelle polyamines |
author_facet |
Igor Pottosin Igor Pottosin Miguel Olivas-Aguirre Oxana Dobrovinskaya Isaac Zepeda-Jazo Sergey Shabala Sergey Shabala |
author_sort |
Igor Pottosin |
title |
Modulation of Ion Transport Across Plant Membranes by Polyamines: Understanding Specific Modes of Action Under Stress |
title_short |
Modulation of Ion Transport Across Plant Membranes by Polyamines: Understanding Specific Modes of Action Under Stress |
title_full |
Modulation of Ion Transport Across Plant Membranes by Polyamines: Understanding Specific Modes of Action Under Stress |
title_fullStr |
Modulation of Ion Transport Across Plant Membranes by Polyamines: Understanding Specific Modes of Action Under Stress |
title_full_unstemmed |
Modulation of Ion Transport Across Plant Membranes by Polyamines: Understanding Specific Modes of Action Under Stress |
title_sort |
modulation of ion transport across plant membranes by polyamines: understanding specific modes of action under stress |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Plant Science |
issn |
1664-462X |
publishDate |
2021-01-01 |
description |
This work critically discusses the direct and indirect effects of natural polyamines and their catabolites such as reactive oxygen species and γ-aminobutyric acid on the activity of key plant ion-transporting proteins such as plasma membrane H+ and Ca2+ ATPases and K+-selective and cation channels in the plasma membrane and tonoplast, in the context of their involvement in stress responses. Docking analysis predicts a distinct binding for putrescine and longer polyamines within the pore of the vacuolar TPC1/SV channel, one of the key determinants of the cell ionic homeostasis and signaling under stress conditions, and an additional site for spermine, which overlaps with the cytosolic regulatory Ca2+-binding site. Several unresolved problems are summarized, including the correct estimates of the subcellular levels of polyamines and their catabolites, their unexplored effects on nucleotide-gated and glutamate receptor channels of cell membranes and Ca2+-permeable and K+-selective channels in the membranes of plant mitochondria and chloroplasts, and pleiotropic mechanisms of polyamines’ action on H+ and Ca2+ pumps. |
topic |
abiotic stress Ca2+ ATPase H+-ATPase ion channel organelle polyamines |
url |
https://www.frontiersin.org/articles/10.3389/fpls.2020.616077/full |
work_keys_str_mv |
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