Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate
Itaconate is derived from the tricarboxylic acid (TCA) cycle intermediate <i>cis</i>-aconitate and links innate immunity and metabolism. Its synthesis is altered in inflammation-related disorders and it therefore has potential as clinical biomarker. Mesaconate and citraconate are natural...
Main Authors: | Moritz Winterhoff, Fangfang Chen, Nishika Sahini, Thomas Ebensen, Maike Kuhn, Volkhard Kaever, Heike Bähre, Frank Pessler |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-04-01
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Series: | Metabolites |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-1989/11/5/270 |
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