Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate

Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate

Itaconate is derived from the tricarboxylic acid (TCA) cycle intermediate <i>cis</i>-aconitate and links innate immunity and metabolism. Its synthesis is altered in inflammation-related disorders and it therefore has potential as clinical biomarker. Mesaconate and citraconate are natural...

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Bibliographic Details
Main Authors: Moritz Winterhoff, Fangfang Chen, Nishika Sahini, Thomas Ebensen, Maike Kuhn, Volkhard Kaever, Heike Bähre, Frank Pessler
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Metabolites
Subjects:
biomarker
CAD
<i>cis</i>-aconitate decarboxylase
citraconate
Irg1
itaconate
Online Access:https://www.mdpi.com/2218-1989/11/5/270

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