Antibiotics, Resistome and Resistance Mechanisms: A Bacterial Perspective
History of mankind is regarded as struggle against infectious diseases. Rather than observing the withering away of bacterial diseases, antibiotic resistance has emerged as a serious global health concern. Medium of antibiotic resistance in bacteria varies greatly and comprises of target protection,...
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doaj-db0f7d0777c84724b3ebbe271a960ae72020-11-24T23:46:40ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-09-01910.3389/fmicb.2018.02066377549Antibiotics, Resistome and Resistance Mechanisms: A Bacterial PerspectiveInsha Sultan0Safikur Rahman1Arif Tasleem Jan2Mohammad Tahir Siddiqui3Aftab Hossain Mondal4Qazi Mohd Rizwanul Haq5Department of Biosciences, Jamia Millia Islamia, New Delhi, IndiaDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan, South KoreaSchool of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri, IndiaDepartment of Biosciences, Jamia Millia Islamia, New Delhi, IndiaDepartment of Biosciences, Jamia Millia Islamia, New Delhi, IndiaDepartment of Biosciences, Jamia Millia Islamia, New Delhi, IndiaHistory of mankind is regarded as struggle against infectious diseases. Rather than observing the withering away of bacterial diseases, antibiotic resistance has emerged as a serious global health concern. Medium of antibiotic resistance in bacteria varies greatly and comprises of target protection, target substitution, antibiotic detoxification and block of intracellular antibiotic accumulation. Further aggravation to prevailing situation arose on observing bacteria gradually becoming resistant to different classes of antibiotics through acquisition of resistance genes from same and different genera of bacteria. Attributing bacteria with feature of better adaptability, dispersal of antibiotic resistance genes to minimize effects of antibiotics by various means including horizontal gene transfer (conjugation, transformation, and transduction), Mobile genetic elements (plasmids, transposons, insertion sequences, integrons, and integrative-conjugative elements) and bacterial toxin-antitoxin system led to speedy bloom of antibiotic resistance amongst bacteria. Proficiency of bacteria to obtain resistance genes generated an unpleasant situation; a grave, but a lot unacknowledged, feature of resistance gene transfer.https://www.frontiersin.org/article/10.3389/fmicb.2018.02066/fullantibioticsbacteriabacterial resistancediseaseshealth care |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Insha Sultan Safikur Rahman Arif Tasleem Jan Mohammad Tahir Siddiqui Aftab Hossain Mondal Qazi Mohd Rizwanul Haq |
spellingShingle |
Insha Sultan Safikur Rahman Arif Tasleem Jan Mohammad Tahir Siddiqui Aftab Hossain Mondal Qazi Mohd Rizwanul Haq Antibiotics, Resistome and Resistance Mechanisms: A Bacterial Perspective Frontiers in Microbiology antibiotics bacteria bacterial resistance diseases health care |
author_facet |
Insha Sultan Safikur Rahman Arif Tasleem Jan Mohammad Tahir Siddiqui Aftab Hossain Mondal Qazi Mohd Rizwanul Haq |
author_sort |
Insha Sultan |
title |
Antibiotics, Resistome and Resistance Mechanisms: A Bacterial Perspective |
title_short |
Antibiotics, Resistome and Resistance Mechanisms: A Bacterial Perspective |
title_full |
Antibiotics, Resistome and Resistance Mechanisms: A Bacterial Perspective |
title_fullStr |
Antibiotics, Resistome and Resistance Mechanisms: A Bacterial Perspective |
title_full_unstemmed |
Antibiotics, Resistome and Resistance Mechanisms: A Bacterial Perspective |
title_sort |
antibiotics, resistome and resistance mechanisms: a bacterial perspective |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2018-09-01 |
description |
History of mankind is regarded as struggle against infectious diseases. Rather than observing the withering away of bacterial diseases, antibiotic resistance has emerged as a serious global health concern. Medium of antibiotic resistance in bacteria varies greatly and comprises of target protection, target substitution, antibiotic detoxification and block of intracellular antibiotic accumulation. Further aggravation to prevailing situation arose on observing bacteria gradually becoming resistant to different classes of antibiotics through acquisition of resistance genes from same and different genera of bacteria. Attributing bacteria with feature of better adaptability, dispersal of antibiotic resistance genes to minimize effects of antibiotics by various means including horizontal gene transfer (conjugation, transformation, and transduction), Mobile genetic elements (plasmids, transposons, insertion sequences, integrons, and integrative-conjugative elements) and bacterial toxin-antitoxin system led to speedy bloom of antibiotic resistance amongst bacteria. Proficiency of bacteria to obtain resistance genes generated an unpleasant situation; a grave, but a lot unacknowledged, feature of resistance gene transfer. |
topic |
antibiotics bacteria bacterial resistance diseases health care |
url |
https://www.frontiersin.org/article/10.3389/fmicb.2018.02066/full |
work_keys_str_mv |
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