The Effect of Preoperative Administration of Duloxetine on Postoperative Pain After Laparoscopic Myomectomy
The purpose of this study was to evaluate the effect of preoperative administration of duloxetine on postoperative pain after laparoscopic myomectomy. In this double-blind clinical trial study, 57 patients aged 18-55 years with ASA I or II undergoing laparoscopic myomectomy involved. The case group...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Tehran University of Medical Sciences
2020-07-01
|
Series: | Acta Medica Iranica |
Subjects: | |
Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/8161 |
id |
doaj-db1539eed8e846079d3e1186146efaad |
---|---|
record_format |
Article |
spelling |
doaj-db1539eed8e846079d3e1186146efaad2020-11-25T03:40:09ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942020-07-0158310.18502/acta.v58i3.37758161The Effect of Preoperative Administration of Duloxetine on Postoperative Pain After Laparoscopic MyomectomyMaryam Hatami0Arezoo Kheirati1Shekoufeh Behdad2Atiye Javaheri3Sedighe Vaziribozorg4Departments of Anesthesiology, Pain Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Departments of Anesthesiology, Pain Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Departments of Anesthesiology, Pain Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Departments of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Department of Otolaryngology-Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. The purpose of this study was to evaluate the effect of preoperative administration of duloxetine on postoperative pain after laparoscopic myomectomy. In this double-blind clinical trial study, 57 patients aged 18-55 years with ASA I or II undergoing laparoscopic myomectomy involved. The case group received oral duloxetine 60 mg, and the control group received placebo 2 hours before the surgery. Pain scores, total analgesic consumption during 24 hours, recovery discharging time, nausea, vomiting, dizziness, and hemodynamic changes were recorded and compared between two groups. The pain severity was significantly lower in the case group at 2, 12, and 24 hours after the operation (P<0.05). There were no significant differences in dizziness, nausea, vomiting, systolic and diastolic blood pressure, and heart rate of patients between two groups before the surgery, 5 and 30 minutes after the induction, and after the recovery. Duloxetine administration prior to laparoscopic surgery myomectomy can reduce postoperative pain without inducing side effects in patients. https://acta.tums.ac.ir/index.php/acta/article/view/8161Postoperative painDuloxetineMyomectomy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maryam Hatami Arezoo Kheirati Shekoufeh Behdad Atiye Javaheri Sedighe Vaziribozorg |
spellingShingle |
Maryam Hatami Arezoo Kheirati Shekoufeh Behdad Atiye Javaheri Sedighe Vaziribozorg The Effect of Preoperative Administration of Duloxetine on Postoperative Pain After Laparoscopic Myomectomy Acta Medica Iranica Postoperative pain Duloxetine Myomectomy |
author_facet |
Maryam Hatami Arezoo Kheirati Shekoufeh Behdad Atiye Javaheri Sedighe Vaziribozorg |
author_sort |
Maryam Hatami |
title |
The Effect of Preoperative Administration of Duloxetine on Postoperative Pain After Laparoscopic Myomectomy |
title_short |
The Effect of Preoperative Administration of Duloxetine on Postoperative Pain After Laparoscopic Myomectomy |
title_full |
The Effect of Preoperative Administration of Duloxetine on Postoperative Pain After Laparoscopic Myomectomy |
title_fullStr |
The Effect of Preoperative Administration of Duloxetine on Postoperative Pain After Laparoscopic Myomectomy |
title_full_unstemmed |
The Effect of Preoperative Administration of Duloxetine on Postoperative Pain After Laparoscopic Myomectomy |
title_sort |
effect of preoperative administration of duloxetine on postoperative pain after laparoscopic myomectomy |
publisher |
Tehran University of Medical Sciences |
series |
Acta Medica Iranica |
issn |
0044-6025 1735-9694 |
publishDate |
2020-07-01 |
description |
The purpose of this study was to evaluate the effect of preoperative administration of duloxetine on postoperative pain after laparoscopic myomectomy. In this double-blind clinical trial study, 57 patients aged 18-55 years with ASA I or II undergoing laparoscopic myomectomy involved. The case group received oral duloxetine 60 mg, and the control group received placebo 2 hours before the surgery. Pain scores, total analgesic consumption during 24 hours, recovery discharging time, nausea, vomiting, dizziness, and hemodynamic changes were recorded and compared between two groups. The pain severity was significantly lower in the case group at 2, 12, and 24 hours after the operation (P<0.05). There were no significant differences in dizziness, nausea, vomiting, systolic and diastolic blood pressure, and heart rate of patients between two groups before the surgery, 5 and 30 minutes after the induction, and after the recovery. Duloxetine administration prior to laparoscopic surgery myomectomy can reduce postoperative pain without inducing side effects in patients.
|
topic |
Postoperative pain Duloxetine Myomectomy |
url |
https://acta.tums.ac.ir/index.php/acta/article/view/8161 |
work_keys_str_mv |
AT maryamhatami theeffectofpreoperativeadministrationofduloxetineonpostoperativepainafterlaparoscopicmyomectomy AT arezookheirati theeffectofpreoperativeadministrationofduloxetineonpostoperativepainafterlaparoscopicmyomectomy AT shekoufehbehdad theeffectofpreoperativeadministrationofduloxetineonpostoperativepainafterlaparoscopicmyomectomy AT atiyejavaheri theeffectofpreoperativeadministrationofduloxetineonpostoperativepainafterlaparoscopicmyomectomy AT sedighevaziribozorg theeffectofpreoperativeadministrationofduloxetineonpostoperativepainafterlaparoscopicmyomectomy AT maryamhatami effectofpreoperativeadministrationofduloxetineonpostoperativepainafterlaparoscopicmyomectomy AT arezookheirati effectofpreoperativeadministrationofduloxetineonpostoperativepainafterlaparoscopicmyomectomy AT shekoufehbehdad effectofpreoperativeadministrationofduloxetineonpostoperativepainafterlaparoscopicmyomectomy AT atiyejavaheri effectofpreoperativeadministrationofduloxetineonpostoperativepainafterlaparoscopicmyomectomy AT sedighevaziribozorg effectofpreoperativeadministrationofduloxetineonpostoperativepainafterlaparoscopicmyomectomy |
_version_ |
1724536009913270272 |