Adipose PTEN acts as a downstream mediator of a brain-fat axis in environmental enrichment

Adipose PTEN acts as a downstream mediator of a brain-fat axis in environmental enrichment

Background/Objectives: Environmental enrichment (EE) is a physiological model to investigate brain-fat interactions. We previously discovered that EE activates the hypothalamic-sympathoneural adipocyte (HSA) axis via induction of brain-derived neurotrophic factor (BDNF), thus leading to sympathetic...

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Bibliographic Details
Main Authors: Wei Huang, Nicholas J. Queen, Travis B. McMurphy, Seemaab Ali, Ryan K. Wilkins, Bhavya Appana, Lei Cao
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Comprehensive Psychoneuroendocrinology
Subjects:
Environmental enrichment
PTEN
Adipose tissue
Sympathetic nervous system
Lipolysis
AAV
Online Access:http://www.sciencedirect.com/science/article/pii/S2666497620300138

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