Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles
Kaikai Bai,1,2,* Bihong Hong,1,2,* Ran Tan,1,2 Jianlin He,1,2 Zhuan Hong1,2 1Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, Republic of China; 2Technical Innovation Center for Utilization of Marine Biological Resources, Ministry of Natural Resources, Xiamen 361005, Pe...
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doaj-db2b4d0d301a4197845c91ae3833362d2020-11-25T01:46:57ZengDove Medical PressInternational Journal of Nanomedicine1178-20132020-02-01Volume 151187120351932Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium NanoparticlesBai KHong BTan RHe JHong ZKaikai Bai,1,2,* Bihong Hong,1,2,* Ran Tan,1,2 Jianlin He,1,2 Zhuan Hong1,2 1Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, Republic of China; 2Technical Innovation Center for Utilization of Marine Biological Resources, Ministry of Natural Resources, Xiamen 361005, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kaikai BaiThird Institute of Oceanography, Ministry of Natural Resources, No. 184, Daxue Road, Siming District, Xiamen, Fujian 361005, People’s Republic of ChinaTel +86 592 2195309Fax +86 592 2190818Email kkbai@tio.org.cnBackground: Selenium (Se) is an indispensable trace element required for animals and human beings, whereas Se-deficiency can accelerate the development of acute gastric injury induced by over-consumption of alcohol. Selenium nanoparticles (SeNPs), as a special Se-supplement with favorable properties and unique bioactivities, are expected to play a passive role in gastroprotection. To the best of our knowledge, the gastroprotective potential of SeNPs is unknown and also, a rapid preparation of orally stable SeNPs available for prospective commercial application in the clinic is needed. Thus, SeNPs-embedded chitosan microspheres (SeNPs-CM) were developed to deliver SeNPs, and their gastroprotective potential was evaluated.Results: Herein, a rapid, eco-friendly and economic preparation process, composed of synthesis of SeNPs decorated by chitosan (CS), purification of CS-SeNPs by ultra-filtration (UF) and spray-drying of the purified CS-SeNPs, was introduced to prepare SeNPs-CM. The uniformly distributed SeNPs with a nanosize range of 60 nm were loaded into CS-microspheres, and they could be released from the microspheres in gastric conditions. In addition, SeNPs-CM were safer than selenite in terms of Se dose, with a LD50 of around 8-fold of that of selenite, and it could efficiently enhance the Se retention in Se-deficient Wistar rats. Furthermore, SeNPs-CM pre-treatment might significantly attenuate the ethanol-induced gastric mucosal damage, based on histological evaluation. It might be partly attributed to the systematic antioxidant activities of SeNPs-CM, reflected by the reduction in lipid peroxidation, the augmentation in antioxidant enzymatic activity as well as decreasing aggressive nitric oxides (NO).Conclusion: SeNPs-CM could be taken into consideration as a prospective Se-supplement for the oral delivery of SeNPs, with prominent gastroprotective effect against ethanol-induced mucosal injury.Keywords: selenium nanoparticles, gastric mucosal injury, gastroprotection, antioxidanthttps://www.dovepress.com/selenium-nanoparticles-embedded-chitosan-microspheres-and-their-effect-peer-reviewed-article-IJNselenium nanoparticlesgastric mucosal injurygastroprotectionantioxidant |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bai K Hong B Tan R He J Hong Z |
spellingShingle |
Bai K Hong B Tan R He J Hong Z Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles International Journal of Nanomedicine selenium nanoparticles gastric mucosal injury gastroprotection antioxidant |
author_facet |
Bai K Hong B Tan R He J Hong Z |
author_sort |
Bai K |
title |
Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles |
title_short |
Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles |
title_full |
Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles |
title_fullStr |
Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles |
title_full_unstemmed |
Selenium Nanoparticles-Embedded Chitosan Microspheres and Their Effects Upon Alcohol-Induced Gastric Mucosal Injury in Rats: Rapid Preparation, Oral Delivery, and Gastroprotective Potential of Selenium Nanoparticles |
title_sort |
selenium nanoparticles-embedded chitosan microspheres and their effects upon alcohol-induced gastric mucosal injury in rats: rapid preparation, oral delivery, and gastroprotective potential of selenium nanoparticles |
publisher |
Dove Medical Press |
series |
International Journal of Nanomedicine |
issn |
1178-2013 |
publishDate |
2020-02-01 |
description |
Kaikai Bai,1,2,* Bihong Hong,1,2,* Ran Tan,1,2 Jianlin He,1,2 Zhuan Hong1,2 1Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, Republic of China; 2Technical Innovation Center for Utilization of Marine Biological Resources, Ministry of Natural Resources, Xiamen 361005, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kaikai BaiThird Institute of Oceanography, Ministry of Natural Resources, No. 184, Daxue Road, Siming District, Xiamen, Fujian 361005, People’s Republic of ChinaTel +86 592 2195309Fax +86 592 2190818Email kkbai@tio.org.cnBackground: Selenium (Se) is an indispensable trace element required for animals and human beings, whereas Se-deficiency can accelerate the development of acute gastric injury induced by over-consumption of alcohol. Selenium nanoparticles (SeNPs), as a special Se-supplement with favorable properties and unique bioactivities, are expected to play a passive role in gastroprotection. To the best of our knowledge, the gastroprotective potential of SeNPs is unknown and also, a rapid preparation of orally stable SeNPs available for prospective commercial application in the clinic is needed. Thus, SeNPs-embedded chitosan microspheres (SeNPs-CM) were developed to deliver SeNPs, and their gastroprotective potential was evaluated.Results: Herein, a rapid, eco-friendly and economic preparation process, composed of synthesis of SeNPs decorated by chitosan (CS), purification of CS-SeNPs by ultra-filtration (UF) and spray-drying of the purified CS-SeNPs, was introduced to prepare SeNPs-CM. The uniformly distributed SeNPs with a nanosize range of 60 nm were loaded into CS-microspheres, and they could be released from the microspheres in gastric conditions. In addition, SeNPs-CM were safer than selenite in terms of Se dose, with a LD50 of around 8-fold of that of selenite, and it could efficiently enhance the Se retention in Se-deficient Wistar rats. Furthermore, SeNPs-CM pre-treatment might significantly attenuate the ethanol-induced gastric mucosal damage, based on histological evaluation. It might be partly attributed to the systematic antioxidant activities of SeNPs-CM, reflected by the reduction in lipid peroxidation, the augmentation in antioxidant enzymatic activity as well as decreasing aggressive nitric oxides (NO).Conclusion: SeNPs-CM could be taken into consideration as a prospective Se-supplement for the oral delivery of SeNPs, with prominent gastroprotective effect against ethanol-induced mucosal injury.Keywords: selenium nanoparticles, gastric mucosal injury, gastroprotection, antioxidant |
topic |
selenium nanoparticles gastric mucosal injury gastroprotection antioxidant |
url |
https://www.dovepress.com/selenium-nanoparticles-embedded-chitosan-microspheres-and-their-effect-peer-reviewed-article-IJN |
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