Digital Resilience Biomarkers for Personalized Health Maintenance and Disease Prevention
Health maintenance and disease prevention strategies become increasingly prioritized with increasing health and economic burden of chronic, lifestyle-related diseases. A key element in these strategies is the empowerment of individuals to control their health. Self-measurement plays an essential rol...
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doaj-db2dc56ea4db4fa9948a24970103d17a2021-01-22T16:03:24ZengFrontiers Media S.A.Frontiers in Digital Health2673-253X2021-01-01210.3389/fdgth.2020.614670614670Digital Resilience Biomarkers for Personalized Health Maintenance and Disease PreventionWillem van den Brink0Robbert Bloem1Adithya Ananth2Thiru Kanagasabapathi3Arjen Amelink4Jildau Bouwman5Gerwin Gelinck6Sjaak van Veen7Andre Boorsma8Suzan Wopereis9Department of Microbiology and Systems Biology, Netherlands Organization for Applied Scientific Research (TNO), Zeist, NetherlandsDepartment of Environmental Modeling Sensing and Analysis, Netherlands Organization for Applied Scientific Research (TNO), Utrecht, NetherlandsDepartment of Optics, Netherlands Organization for Applied Scientific Research (TNO), Delft, NetherlandsHolst Center, Netherlands Organization for Applied Scientific Research (TNO), Eindhoven, NetherlandsDepartment of Optics, Netherlands Organization for Applied Scientific Research (TNO), Delft, NetherlandsDepartment of Microbiology and Systems Biology, Netherlands Organization for Applied Scientific Research (TNO), Zeist, NetherlandsHolst Center, Netherlands Organization for Applied Scientific Research (TNO), Eindhoven, NetherlandsDepartment of Environmental Modeling Sensing and Analysis, Netherlands Organization for Applied Scientific Research (TNO), Utrecht, NetherlandsDepartment of Microbiology and Systems Biology, Netherlands Organization for Applied Scientific Research (TNO), Zeist, NetherlandsDepartment of Microbiology and Systems Biology, Netherlands Organization for Applied Scientific Research (TNO), Zeist, NetherlandsHealth maintenance and disease prevention strategies become increasingly prioritized with increasing health and economic burden of chronic, lifestyle-related diseases. A key element in these strategies is the empowerment of individuals to control their health. Self-measurement plays an essential role in achieving such empowerment. Digital measurements have the advantage of being measured non-invasively, passively, continuously, and in a real-world context. An important question is whether such measurement can sensitively measure subtle disbalances in the progression toward disease, as well as the subtle effects of, for example, nutritional improvement. The concept of resilience biomarkers, defined as the dynamic evaluation of the biological response to an external challenge, has been identified as a viable strategy to measure these subtle effects. In this review, we explore the potential of integrating this concept with digital physiological measurements to come to digital resilience biomarkers. Additionally, we discuss the potential of wearable, non-invasive, and continuous measurement of molecular biomarkers. These types of innovative measurements may, in the future, also serve as a digital resilience biomarker to provide even more insight into the personal biological dynamics of an individual. Altogether, digital resilience biomarkers are envisioned to allow for the measurement of subtle effects of health maintenance and disease prevention strategies in a real-world context and thereby give personalized feedback to improve health.https://www.frontiersin.org/articles/10.3389/fdgth.2020.614670/fulldigital biomarkerpreventionlifestyle interventionoptical sensingwearable sensorsresilience |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Willem van den Brink Robbert Bloem Adithya Ananth Thiru Kanagasabapathi Arjen Amelink Jildau Bouwman Gerwin Gelinck Sjaak van Veen Andre Boorsma Suzan Wopereis |
spellingShingle |
Willem van den Brink Robbert Bloem Adithya Ananth Thiru Kanagasabapathi Arjen Amelink Jildau Bouwman Gerwin Gelinck Sjaak van Veen Andre Boorsma Suzan Wopereis Digital Resilience Biomarkers for Personalized Health Maintenance and Disease Prevention Frontiers in Digital Health digital biomarker prevention lifestyle intervention optical sensing wearable sensors resilience |
author_facet |
Willem van den Brink Robbert Bloem Adithya Ananth Thiru Kanagasabapathi Arjen Amelink Jildau Bouwman Gerwin Gelinck Sjaak van Veen Andre Boorsma Suzan Wopereis |
author_sort |
Willem van den Brink |
title |
Digital Resilience Biomarkers for Personalized Health Maintenance and Disease Prevention |
title_short |
Digital Resilience Biomarkers for Personalized Health Maintenance and Disease Prevention |
title_full |
Digital Resilience Biomarkers for Personalized Health Maintenance and Disease Prevention |
title_fullStr |
Digital Resilience Biomarkers for Personalized Health Maintenance and Disease Prevention |
title_full_unstemmed |
Digital Resilience Biomarkers for Personalized Health Maintenance and Disease Prevention |
title_sort |
digital resilience biomarkers for personalized health maintenance and disease prevention |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Digital Health |
issn |
2673-253X |
publishDate |
2021-01-01 |
description |
Health maintenance and disease prevention strategies become increasingly prioritized with increasing health and economic burden of chronic, lifestyle-related diseases. A key element in these strategies is the empowerment of individuals to control their health. Self-measurement plays an essential role in achieving such empowerment. Digital measurements have the advantage of being measured non-invasively, passively, continuously, and in a real-world context. An important question is whether such measurement can sensitively measure subtle disbalances in the progression toward disease, as well as the subtle effects of, for example, nutritional improvement. The concept of resilience biomarkers, defined as the dynamic evaluation of the biological response to an external challenge, has been identified as a viable strategy to measure these subtle effects. In this review, we explore the potential of integrating this concept with digital physiological measurements to come to digital resilience biomarkers. Additionally, we discuss the potential of wearable, non-invasive, and continuous measurement of molecular biomarkers. These types of innovative measurements may, in the future, also serve as a digital resilience biomarker to provide even more insight into the personal biological dynamics of an individual. Altogether, digital resilience biomarkers are envisioned to allow for the measurement of subtle effects of health maintenance and disease prevention strategies in a real-world context and thereby give personalized feedback to improve health. |
topic |
digital biomarker prevention lifestyle intervention optical sensing wearable sensors resilience |
url |
https://www.frontiersin.org/articles/10.3389/fdgth.2020.614670/full |
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