Post-Receptor Inhibitors of the GHR-JAK2-STAT Pathway in the Growth Hormone Signal Transduction

Post-Receptor Inhibitors of the GHR-JAK2-STAT Pathway in the Growth Hormone Signal Transduction

The growth hormone (GH) plays a key role in the regulation of metabolic processes in an organism. Determination of the correct structure and functioning of the growth hormone receptor (GHR) allowed for a more detailed research of its post-receptor regulators, which substantially influences its signa...

Full description

Bibliographic Details
Main Authors:	Maciej Wójcik, Agata Krawczyńska, Hanna Antushevich, Andrzej Przemysław Herman
Format:	Article
Language:	English
Published:	MDPI AG 2018-06-01
Series:	International Journal of Molecular Sciences
Subjects:	growth hormone receptor STAT SOCS protein tyrosine phosphatase SIRT SHP PIAS SIRPα1
Online Access:	http://www.mdpi.com/1422-0067/19/7/1843

Similar Items

Negative regulators of STAT3 signaling pathway in cancers
by: Wu M, et al.
Published: (2019-05-01)

Phosphatase-independent functions of SHP2 and its regulation by small molecule compounds
by: Wenjie Guo, et al.
Published: (2020-11-01)

Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity
by: Darienne R. Myers, et al.
Published: (2020-09-01)

Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy
by: Tzu-Ting Huang, et al.
Published: (2017-06-01)

Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling
by: Mihwa Kim, et al.
Published: (2018-09-01)

Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats
by: Bin Liu, et al.
Published: (2020-12-01)

Lycorine exerts antitumor activity against osteosarcoma cells in vitro and in vivo xenograft model through the JAK2/STAT3 pathway
by: Hu H, et al.
Published: (2019-07-01)

Shp1 in Solid Cancers and Their Therapy
by: Alessia Varone, et al.
Published: (2020-06-01)

Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1
by: Jung-Chen Su, et al.
Published: (2018-01-01)

The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling
by: Jessica Fiebelkow, et al.
Published: (2021-09-01)

TARGETED ANALYSIS OF JAK-STAT-SOCS GENES IN DAIRY CATTLE
by: Arun Sondur Jayappa, et al.
Published: (2015-12-01)

SHP2, SOCS3 and PIAS3 Expression Patterns in Medulloblastomas: Relevance to STAT3 Activation and Resveratrol-Suppressed STAT3 Signaling
by: Cong Li, et al.
Published: (2016-12-01)

Mechanisms of action of transforming growth factor beta and activin in haematopoietic cells
by: Valderrama-Carvajal, Hector F.
Published: (2007)

Expression analysis of protein inhibitor of activated STAT (PIAS) genes in IFNβ-treated multiple sclerosis patients
by: Taheri M, et al.
Published: (2018-12-01)

SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model
by: Jihong Jiang, et al.
Published: (2020-09-01)

Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma
by: Sarita Saraswati, et al.
Published: (2019-10-01)

The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity
by: Yvonn Heun, et al.
Published: (2019-09-01)

Implication de la signalisation SHP-2 ERK/MAPK dans le maintien de l’homéostasie de l’épithélium colique
by: Langlois, Ariane
Published: (2017)

Yellow Fever Virus Down-Regulates mRNA Expression of SOCS1 in the Initial Phase of Infection in Human Cell Lines
by: Michael B. Yakass, et al.
Published: (2020-07-01)

Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production
by: Muhammad Zahoor Khan, et al.
Published: (2020-11-01)

Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2)
by: Se Jeong Kwon, et al.
Published: (2021-02-01)

JAK-1/STAT-3 pathway mediated role in aging cerebellar cortex degenerative changes of albino wistar rats
by: Ahmed S. Ahmed
Published: (2021-01-01)

Atractylenolide II Induces Apoptosis of Prostate Cancer Cells through Regulation of AR and JAK2/STAT3 Signaling Pathways
by: Jing Wang, et al.
Published: (2018-12-01)

Inhibition of JAK2/STAT3/SOCS3 signaling attenuates atherosclerosis in rabbit
by: Xilan Yang, et al.
Published: (2020-03-01)

Nrf2-SHP Cascade-Mediated STAT3 Inactivation Contributes to AMPK-Driven Protection Against Endotoxic Inflammation
by: Hui Gong, et al.
Published: (2020-03-01)

Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain
by: Braun Sandra, et al.
Published: (2002-08-01)

Expression and Clinical Significance of SHP2 in the Tumor Tissues of Smokers with Lung Cancer
by: Xuemei ZHAN, et al.
Published: (2010-09-01)

LINC00669 insulates the JAK/STAT suppressor SOCS1 to promote nasopharyngeal cancer cell proliferation and invasion
by: Xiang Qing, et al.
Published: (2020-08-01)

Albendazole Exhibits Anti-Neoplastic Actions against Gastric Cancer Cells by Affecting STAT3 and STAT5 Activation by Pleiotropic Mechanism(s)
by: Min Hee Yang, et al.
Published: (2021-03-01)

Expression Analysis of Protein Inhibitor of Activated STAT in Inflammatory Demyelinating Polyradiculoneuropathy
by: Soudeh Ghafouri-Fard, et al.
Published: (2021-05-01)

Liensinine suppresses STAT3-dependent HK2 expression through elevating SHP-1 to induce apoptosis in hepatocellular carcinoma cells in vitro and in vivo
by: Guangwen Shu, et al.
Published: (2018-06-01)

Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells
by: Chiara Porro, et al.
Published: (2019-06-01)

Chrysin inhibits sphere formation in SMMC-7721 cells via modulation of SHP-1/STAT3 signaling pathway
by: Zhang Y, et al.
Published: (2019-04-01)

Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2
by: Kostrzewa T, et al.
Published: (2018-12-01)

Rôles de la protéine tyrosine phosphatase SHP-2 dans l'inflammation intestinale et le cancer colorectal associé à la colite
by: Coulombe, Geneviève
Published: (2015)

STAT e SOCS na modulação funcional de células dendríticas derivadas de doadores saudáveis e pacientes com câncer.
by: Patrícia Argenta Toniolo
Published: (2014)

STAT e SOCS na modulação funcional de células dendríticas derivadas de doadores saudáveis e pacientes com câncer.
by: Toniolo, Patrícia Argenta
Published: (2014)

Curcumin Suppressed Activation of Dendritic Cells via JAK/STAT/SOCS Signal in Mice with Experimental Colitis
by: Hai-mei Zhao, et al.
Published: (2016-11-01)

SOCS3 Promotes ALV-J Virus Replication via Inhibiting JAK2/STAT3 Phosphorylation During Infection
by: Guodong Mo, et al.
Published: (2021-09-01)

Inhibition of the SOCS1-JAK2-STAT3 Signaling Pathway Confers Neuroprotection in Rats with Ischemic Stroke
by: Xiao-Lei Wang, et al.
Published: (2017-11-01)