Papillary squamous cell carcinoma successfully treated with bronchoscopic intratumoral injections of cisplatin and Endostar: a case report
Squamous cell carcinoma (SCC) is a malignant epithelial tumor originating from the bronchial epithelium that shows keratosis and/or intercellular bridges. Papillary squamous cell carcinoma (PSCC) is an extremely rare subtype of SCC that manifests with a unique intrabronchial papillary growth pattern...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2021-09-01
|
Series: | Journal of International Medical Research |
Online Access: | https://doi.org/10.1177/03000605211047077 |
id |
doaj-db38183d857a4a39b62344f0eea8a54c |
---|---|
record_format |
Article |
spelling |
doaj-db38183d857a4a39b62344f0eea8a54c2021-09-29T00:03:19ZengSAGE PublishingJournal of International Medical Research1473-23002021-09-014910.1177/03000605211047077Papillary squamous cell carcinoma successfully treated with bronchoscopic intratumoral injections of cisplatin and Endostar: a case reportYong WangYue LiBin YinXiaoping YangFengchan WangHaiyan WangWenqing JiangSquamous cell carcinoma (SCC) is a malignant epithelial tumor originating from the bronchial epithelium that shows keratosis and/or intercellular bridges. Papillary squamous cell carcinoma (PSCC) is an extremely rare subtype of SCC that manifests with a unique intrabronchial papillary growth pattern. Surgical resection is still the first recommendation for localized noninvasive SCC. However, some patients are not candidates for surgical resection. With the development of interventional pulmonology, bronchoscopic interventional therapy has played a key role in the treatment of central airway tumors. Here, we report a case of noninvasive PSCC in the airway treated with an electric snare, argon plasma coagulation (APC), and cryotherapy. After removing the tumor by electrotomy, cryotherapy, and APC, the tumor was injected with Endostar 15 mg (3 ml) and cisplatin 20 mg (diluted to 3 ml with 0.9% normal saline) in six separate sites, once every 21 days. The tumor was eliminated, and the treatment was stopped after four treatment cycles. During the 1-year follow-up, there was no recurrence of PSCC in the airway. In this case, submucosal injections of Endostar combined with cisplatin was a feasible and effective endoscopic method for treating a low-grade intratracheal malignant tumor.https://doi.org/10.1177/03000605211047077 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong Wang Yue Li Bin Yin Xiaoping Yang Fengchan Wang Haiyan Wang Wenqing Jiang |
spellingShingle |
Yong Wang Yue Li Bin Yin Xiaoping Yang Fengchan Wang Haiyan Wang Wenqing Jiang Papillary squamous cell carcinoma successfully treated with bronchoscopic intratumoral injections of cisplatin and Endostar: a case report Journal of International Medical Research |
author_facet |
Yong Wang Yue Li Bin Yin Xiaoping Yang Fengchan Wang Haiyan Wang Wenqing Jiang |
author_sort |
Yong Wang |
title |
Papillary squamous cell carcinoma successfully treated with bronchoscopic intratumoral injections of cisplatin and Endostar: a case report |
title_short |
Papillary squamous cell carcinoma successfully treated with bronchoscopic intratumoral injections of cisplatin and Endostar: a case report |
title_full |
Papillary squamous cell carcinoma successfully treated with bronchoscopic intratumoral injections of cisplatin and Endostar: a case report |
title_fullStr |
Papillary squamous cell carcinoma successfully treated with bronchoscopic intratumoral injections of cisplatin and Endostar: a case report |
title_full_unstemmed |
Papillary squamous cell carcinoma successfully treated with bronchoscopic intratumoral injections of cisplatin and Endostar: a case report |
title_sort |
papillary squamous cell carcinoma successfully treated with bronchoscopic intratumoral injections of cisplatin and endostar: a case report |
publisher |
SAGE Publishing |
series |
Journal of International Medical Research |
issn |
1473-2300 |
publishDate |
2021-09-01 |
description |
Squamous cell carcinoma (SCC) is a malignant epithelial tumor originating from the bronchial epithelium that shows keratosis and/or intercellular bridges. Papillary squamous cell carcinoma (PSCC) is an extremely rare subtype of SCC that manifests with a unique intrabronchial papillary growth pattern. Surgical resection is still the first recommendation for localized noninvasive SCC. However, some patients are not candidates for surgical resection. With the development of interventional pulmonology, bronchoscopic interventional therapy has played a key role in the treatment of central airway tumors. Here, we report a case of noninvasive PSCC in the airway treated with an electric snare, argon plasma coagulation (APC), and cryotherapy. After removing the tumor by electrotomy, cryotherapy, and APC, the tumor was injected with Endostar 15 mg (3 ml) and cisplatin 20 mg (diluted to 3 ml with 0.9% normal saline) in six separate sites, once every 21 days. The tumor was eliminated, and the treatment was stopped after four treatment cycles. During the 1-year follow-up, there was no recurrence of PSCC in the airway. In this case, submucosal injections of Endostar combined with cisplatin was a feasible and effective endoscopic method for treating a low-grade intratracheal malignant tumor. |
url |
https://doi.org/10.1177/03000605211047077 |
work_keys_str_mv |
AT yongwang papillarysquamouscellcarcinomasuccessfullytreatedwithbronchoscopicintratumoralinjectionsofcisplatinandendostaracasereport AT yueli papillarysquamouscellcarcinomasuccessfullytreatedwithbronchoscopicintratumoralinjectionsofcisplatinandendostaracasereport AT binyin papillarysquamouscellcarcinomasuccessfullytreatedwithbronchoscopicintratumoralinjectionsofcisplatinandendostaracasereport AT xiaopingyang papillarysquamouscellcarcinomasuccessfullytreatedwithbronchoscopicintratumoralinjectionsofcisplatinandendostaracasereport AT fengchanwang papillarysquamouscellcarcinomasuccessfullytreatedwithbronchoscopicintratumoralinjectionsofcisplatinandendostaracasereport AT haiyanwang papillarysquamouscellcarcinomasuccessfullytreatedwithbronchoscopicintratumoralinjectionsofcisplatinandendostaracasereport AT wenqingjiang papillarysquamouscellcarcinomasuccessfullytreatedwithbronchoscopicintratumoralinjectionsofcisplatinandendostaracasereport |
_version_ |
1716865085331210240 |