Cardiovascular system diseases in patients with polycystic ovary syndrome – the role of inflammation process in this pathology and possibility of early diagnosis and prevention
Polycystic ovary syndrome is a disorder which affects 5–10% of women in reproductive age. PCOS is a cause of hyperandrogenism, menstrual disorders and infertility. The most common clinical symptoms are hirsutism, acne and obesity. Patients often suffer from metabolic disorders: insulin resistance, h...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Institute of Rural Health
2016-09-01
|
Series: | Annals of Agricultural and Environmental Medicine |
Subjects: | |
Online Access: | http://www.journalssystem.com/aaem/Cardiovascular-system-diseases-in-patients-with-polycystic-ovary-syndrome-the-role-of-inflammation-process-in-this-pathology-and-possibility-of-early-diagnosis-and-prevention,72466,0,2.html |
id |
doaj-db38aa0947e44fbfa36279fbb1855b2e |
---|---|
record_format |
Article |
spelling |
doaj-db38aa0947e44fbfa36279fbb1855b2e2020-11-24T22:32:27ZengInstitute of Rural HealthAnnals of Agricultural and Environmental Medicine1232-19661898-22632016-09-0123453754110.5604/12321966.122684272466Cardiovascular system diseases in patients with polycystic ovary syndrome – the role of inflammation process in this pathology and possibility of early diagnosis and preventionAleksandra Marciniak0Jolanta Nawrocka Rutkowska1Agnieszka Brodowska2Berenika Wiśniewska3Andrzej Starczewski4Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University, Szczecin, PolandDepartment of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University, Szczecin, PolandDepartment of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University, Szczecin, PolandDepartment of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University, Szczecin, PolandDepartment of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University, Szczecin, PolandPolycystic ovary syndrome is a disorder which affects 5–10% of women in reproductive age. PCOS is a cause of hyperandrogenism, menstrual disorders and infertility. The most common clinical symptoms are hirsutism, acne and obesity. Patients often suffer from metabolic disorders: insulin resistance, hyperinsulinemia, dislipidemia, leading to atherosclerosis and others irregularities of the metabolic syndrome. Patients are in the high risk group for cardiovascular diseases (CVD) development because of the metabolic abnormalities. Obesity is observed in 35–60% of women with PCOS. Lean women with PCOS are also exposed to a greater risk of glucose intolerance development and abnormalities in lipid profile than women without PCOS with comparable BMI. Adipocytes are the source of many compounds of the paracrine and endocrine activity. Some of them are also markers and mediators of inflammation. Increased levels of proinflammatory cytokines in blood can promote atherosclerosis and cardiovascular disease. Markers: IL-18, TNF, IL-6 and hs-CRP are often elevated in patients with polycystic ovary syndrome. An increase in inflammatory markers may be an early indicator of the risk of developing insulin resistance and atherosclerosis, and may become a useful prognostic and therapeutic tool for monitoring patients with PCOS: lean and those with overweight and obesity. Assessment of the concentrations of inflammatory markers may become a very useful test in evaluating the risk of developing atherosclerosis and cardiovascular disease, long before their clinical manifestation. It will also allow for the appropriate prophylaxis.http://www.journalssystem.com/aaem/Cardiovascular-system-diseases-in-patients-with-polycystic-ovary-syndrome-the-role-of-inflammation-process-in-this-pathology-and-possibility-of-early-diagnosis-and-prevention,72466,0,2.htmlPCOSCVDinsulin resistanceObesityinflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aleksandra Marciniak Jolanta Nawrocka Rutkowska Agnieszka Brodowska Berenika Wiśniewska Andrzej Starczewski |
spellingShingle |
Aleksandra Marciniak Jolanta Nawrocka Rutkowska Agnieszka Brodowska Berenika Wiśniewska Andrzej Starczewski Cardiovascular system diseases in patients with polycystic ovary syndrome – the role of inflammation process in this pathology and possibility of early diagnosis and prevention Annals of Agricultural and Environmental Medicine PCOS CVD insulin resistance Obesity inflammation |
author_facet |
Aleksandra Marciniak Jolanta Nawrocka Rutkowska Agnieszka Brodowska Berenika Wiśniewska Andrzej Starczewski |
author_sort |
Aleksandra Marciniak |
title |
Cardiovascular system diseases in patients with polycystic ovary syndrome – the role of inflammation process in this pathology and possibility of early diagnosis and prevention |
title_short |
Cardiovascular system diseases in patients with polycystic ovary syndrome – the role of inflammation process in this pathology and possibility of early diagnosis and prevention |
title_full |
Cardiovascular system diseases in patients with polycystic ovary syndrome – the role of inflammation process in this pathology and possibility of early diagnosis and prevention |
title_fullStr |
Cardiovascular system diseases in patients with polycystic ovary syndrome – the role of inflammation process in this pathology and possibility of early diagnosis and prevention |
title_full_unstemmed |
Cardiovascular system diseases in patients with polycystic ovary syndrome – the role of inflammation process in this pathology and possibility of early diagnosis and prevention |
title_sort |
cardiovascular system diseases in patients with polycystic ovary syndrome – the role of inflammation process in this pathology and possibility of early diagnosis and prevention |
publisher |
Institute of Rural Health |
series |
Annals of Agricultural and Environmental Medicine |
issn |
1232-1966 1898-2263 |
publishDate |
2016-09-01 |
description |
Polycystic ovary syndrome is a disorder which affects 5–10% of women in reproductive age. PCOS is a cause of hyperandrogenism, menstrual disorders and infertility. The most common clinical symptoms are hirsutism, acne and obesity. Patients often suffer from metabolic disorders: insulin resistance, hyperinsulinemia, dislipidemia, leading to atherosclerosis and others irregularities of the metabolic syndrome. Patients are in the high risk group for cardiovascular diseases (CVD) development because of the metabolic abnormalities. Obesity is observed in 35–60% of women with PCOS. Lean women with PCOS are also exposed to a greater risk of glucose intolerance development and abnormalities in lipid profile than women without PCOS with comparable BMI. Adipocytes are the source of many compounds of the paracrine and endocrine activity. Some of them are also markers and mediators of inflammation. Increased levels of proinflammatory cytokines in blood can promote atherosclerosis and cardiovascular disease. Markers: IL-18, TNF, IL-6 and hs-CRP are often elevated in patients with polycystic ovary syndrome. An increase in inflammatory markers may be an early indicator of the risk of developing insulin resistance and atherosclerosis, and may become a useful prognostic and therapeutic tool for monitoring patients with PCOS: lean and those with overweight and obesity. Assessment of the concentrations of inflammatory markers may become a very useful test in evaluating the risk of developing atherosclerosis and cardiovascular disease, long before their clinical manifestation. It will also allow for the appropriate prophylaxis. |
topic |
PCOS CVD insulin resistance Obesity inflammation |
url |
http://www.journalssystem.com/aaem/Cardiovascular-system-diseases-in-patients-with-polycystic-ovary-syndrome-the-role-of-inflammation-process-in-this-pathology-and-possibility-of-early-diagnosis-and-prevention,72466,0,2.html |
work_keys_str_mv |
AT aleksandramarciniak cardiovascularsystemdiseasesinpatientswithpolycysticovarysyndrometheroleofinflammationprocessinthispathologyandpossibilityofearlydiagnosisandprevention AT jolantanawrockarutkowska cardiovascularsystemdiseasesinpatientswithpolycysticovarysyndrometheroleofinflammationprocessinthispathologyandpossibilityofearlydiagnosisandprevention AT agnieszkabrodowska cardiovascularsystemdiseasesinpatientswithpolycysticovarysyndrometheroleofinflammationprocessinthispathologyandpossibilityofearlydiagnosisandprevention AT berenikawisniewska cardiovascularsystemdiseasesinpatientswithpolycysticovarysyndrometheroleofinflammationprocessinthispathologyandpossibilityofearlydiagnosisandprevention AT andrzejstarczewski cardiovascularsystemdiseasesinpatientswithpolycysticovarysyndrometheroleofinflammationprocessinthispathologyandpossibilityofearlydiagnosisandprevention |
_version_ |
1725733895362576384 |