Treatment of severe symptomatic hyponatremia
Abstract Hyponatremia is the most common electrolyte abnormality seen in the hospital. Severe symptomatic hyponatremia is associated with grave consequences including cerebral edema, brain herniation, seizures, obtundation, coma, and respiratory arrest. However, rapid correction of chronic severe hy...
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Online Access: | https://doi.org/10.14814/phy2.14265 |
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doaj-db41fc6afd5a4eb2a12c262b9ef8e7f12020-11-25T01:29:41ZengWileyPhysiological Reports2051-817X2019-11-01721n/an/a10.14814/phy2.14265Treatment of severe symptomatic hyponatremiaSrijan Tandukar0Helbert Rondon‐Berrios1Division of Transplant Nephrology Thomas E. Starzl Transplant Institute University of Pittsburgh Medical Center Pittsburgh PennsylvaniaRenal‐Electrolyte Division University of Pittsburgh Medical Center Pittsburgh PennsylvaniaAbstract Hyponatremia is the most common electrolyte abnormality seen in the hospital. Severe symptomatic hyponatremia is associated with grave consequences including cerebral edema, brain herniation, seizures, obtundation, coma, and respiratory arrest. However, rapid correction of chronic severe hyponatremia may lead to osmotic demyelination syndrome (ODS) and even death. Given the serious consequences of severe hyponatremia or its inadvertent overcorrection, it is of paramount importance for the clinician to be aware of the various scenarios in which hyponatremic patients can present and tailor the management strategies accordingly. We present here a case of severe hyponatremia of unknown duration with the presenting plasma sodium level of 95 mmol/L and use it to illustrate the various treatment strategies – proactive, reactive, or rescue therapy – along with the physiological basis to support these approaches.https://doi.org/10.14814/phy2.14265HyponatremiaAntidiuretic hormoneWater diuresis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Srijan Tandukar Helbert Rondon‐Berrios |
spellingShingle |
Srijan Tandukar Helbert Rondon‐Berrios Treatment of severe symptomatic hyponatremia Physiological Reports Hyponatremia Antidiuretic hormone Water diuresis |
author_facet |
Srijan Tandukar Helbert Rondon‐Berrios |
author_sort |
Srijan Tandukar |
title |
Treatment of severe symptomatic hyponatremia |
title_short |
Treatment of severe symptomatic hyponatremia |
title_full |
Treatment of severe symptomatic hyponatremia |
title_fullStr |
Treatment of severe symptomatic hyponatremia |
title_full_unstemmed |
Treatment of severe symptomatic hyponatremia |
title_sort |
treatment of severe symptomatic hyponatremia |
publisher |
Wiley |
series |
Physiological Reports |
issn |
2051-817X |
publishDate |
2019-11-01 |
description |
Abstract Hyponatremia is the most common electrolyte abnormality seen in the hospital. Severe symptomatic hyponatremia is associated with grave consequences including cerebral edema, brain herniation, seizures, obtundation, coma, and respiratory arrest. However, rapid correction of chronic severe hyponatremia may lead to osmotic demyelination syndrome (ODS) and even death. Given the serious consequences of severe hyponatremia or its inadvertent overcorrection, it is of paramount importance for the clinician to be aware of the various scenarios in which hyponatremic patients can present and tailor the management strategies accordingly. We present here a case of severe hyponatremia of unknown duration with the presenting plasma sodium level of 95 mmol/L and use it to illustrate the various treatment strategies – proactive, reactive, or rescue therapy – along with the physiological basis to support these approaches. |
topic |
Hyponatremia Antidiuretic hormone Water diuresis |
url |
https://doi.org/10.14814/phy2.14265 |
work_keys_str_mv |
AT srijantandukar treatmentofseveresymptomatichyponatremia AT helbertrondonberrios treatmentofseveresymptomatichyponatremia |
_version_ |
1725095467861147648 |