Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum
Aim:Hyperemesis gravidarum (HEG) is characterized by severe nausea and vomiting, weight loss and nutritional deficiency. Although exact cause of this condition is still a matter of debate, contribution of oxidative stress to pathogenesis of HEG was demonstrated in some studies. The aim of this study...
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Galenos Yayinevi
2018-12-01
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doaj-db42f22bd4c24037a5fac51c01496e192020-11-25T03:59:42ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882018-12-0156429229810.4274/haseki.401913049054Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis GravidarumFatma Beyazıt0Eren Pek1Hakan Türkön2 Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Çanakkale, Türkiye Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Çanakkale, Türkiye Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, Çanakkale, Türkiye Aim:Hyperemesis gravidarum (HEG) is characterized by severe nausea and vomiting, weight loss and nutritional deficiency. Although exact cause of this condition is still a matter of debate, contribution of oxidative stress to pathogenesis of HEG was demonstrated in some studies. The aim of this study was to investigate the diagnostic value of ischemia-modified albumin (IMA) concentration and IMA/albumin ratio (IMAR) in HEG patients.Methods:One patient group and two control groups were constituted. Pregnant subjects with HEG were included in HEG group (n = 31) and age-, gestational age-, and body mass index (BMI)-matched healthy pregnant women in control group (n = 30). The second control group was constituted from age- and BMI-matched non-pregnant women (n=30). Serum IMA, IMAR blood glucose, albumin, urea, creatinine, alanine aminotransferase and aspartate aminotransferase levels were measured in all subjects.Results:Serum median IMA levels [0.55 (0.43-0.68)] was found to be elevated in HEG patients compared with pregnant [0.52 (0.34-0.61)] and non-pregnant controls [0.48 (0.27-0.57)] (p=˂0.001). IMAR levels were also found to be significantly elevated in HEG patients compared to both control groups. According to correlation analysis, IMA and IMAR levels were only correlated with C-reactive protein levels.Conclusion:Elevated levels of IMA and IMAR in HEG patients might be due to ischemic intrauterine environment. http://www.hasekidergisi.com/archives/archive-detail/article-preview/serum-schemia-modified-albumin-concentration-and-s/21241 Hyperemesis gravidarumischemia-modified albuminischemia-modified albumin/albumin ratiooxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fatma Beyazıt Eren Pek Hakan Türkön |
spellingShingle |
Fatma Beyazıt Eren Pek Hakan Türkön Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum Haseki Tıp Bülteni Hyperemesis gravidarum ischemia-modified albumin ischemia-modified albumin/albumin ratio oxidative stress |
author_facet |
Fatma Beyazıt Eren Pek Hakan Türkön |
author_sort |
Fatma Beyazıt |
title |
Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum |
title_short |
Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum |
title_full |
Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum |
title_fullStr |
Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum |
title_full_unstemmed |
Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum |
title_sort |
serum ischemia-modified albumin concentration and ischemia-modified albumin/albumin ratio in hyperemesis gravidarum |
publisher |
Galenos Yayinevi |
series |
Haseki Tıp Bülteni |
issn |
1302-0072 2147-2688 |
publishDate |
2018-12-01 |
description |
Aim:Hyperemesis gravidarum (HEG) is characterized by severe nausea and vomiting, weight loss and nutritional deficiency. Although exact cause of this condition is still a matter of debate, contribution of oxidative stress to pathogenesis of HEG was demonstrated in some studies. The aim of this study was to investigate the diagnostic value of ischemia-modified albumin (IMA) concentration and IMA/albumin ratio (IMAR) in HEG patients.Methods:One patient group and two control groups were constituted. Pregnant subjects with HEG were included in HEG group (n = 31) and age-, gestational age-, and body mass index (BMI)-matched healthy pregnant women in control group (n = 30). The second control group was constituted from age- and BMI-matched non-pregnant women (n=30). Serum IMA, IMAR blood glucose, albumin, urea, creatinine, alanine aminotransferase and aspartate aminotransferase levels were measured in all subjects.Results:Serum median IMA levels [0.55 (0.43-0.68)] was found to be elevated in HEG patients compared with pregnant [0.52 (0.34-0.61)] and non-pregnant controls [0.48 (0.27-0.57)] (p=˂0.001). IMAR levels were also found to be significantly elevated in HEG patients compared to both control groups. According to correlation analysis, IMA and IMAR levels were only correlated with C-reactive protein levels.Conclusion:Elevated levels of IMA and IMAR in HEG patients might be due to ischemic intrauterine environment. |
topic |
Hyperemesis gravidarum ischemia-modified albumin ischemia-modified albumin/albumin ratio oxidative stress |
url |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/serum-schemia-modified-albumin-concentration-and-s/21241
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work_keys_str_mv |
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