Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease
Wei He,1,2 Yao Luo,1 Jun-Peng Liu,1 Ning Sun,1 Di Guo,1 Ling-Ling Cui,1 Pei-Pei Zheng,1 Si-Min Yao,1 Jie-Fu Yang,1,2 Hua Wang1,2 1Department of Cardiology, Beijing Hospital, National Center of Gerontology, Beijing, People’s Republic of China; 2Chinese Academy of Medical Sciences, Peking Un...
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doaj-db471a8796664a219fcdc5f5bb16602c2020-11-25T03:11:59ZengDove Medical PressClinical Interventions in Aging1178-19982020-09-01Volume 151809182057579Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular DiseaseHe WLuo YLiu JPSun NGuo DCui LLZheng PPYao SMYang JFWang HWei He,1,2 Yao Luo,1 Jun-Peng Liu,1 Ning Sun,1 Di Guo,1 Ling-Ling Cui,1 Pei-Pei Zheng,1 Si-Min Yao,1 Jie-Fu Yang,1,2 Hua Wang1,2 1Department of Cardiology, Beijing Hospital, National Center of Gerontology, Beijing, People’s Republic of China; 2Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Hua Wang; Jie-Fu YangDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, No. 1, Dahua Road, Dongcheng District, Beijing 100730, People’s Republic of ChinaTel +86 13911680467; +86 13601292259Fax +86 10-58115035Email wanghua2764@bjhmoh.cn; yangjiefu2011@126.comObjective: Our study aimed to explore the association between trimethylamine N-oxide and frailty in older adults with cardiovascular disease.Patients and Methods: This cross-sectional study analyzed a total of 451 people aged 65 years or older who underwent comprehensive geriatric assessments. Frailty status was determined using a frailty index constructed with 48 variables according to the cumulative deficits model. Physical frailty and cognitive frailty were also assessed in detail. Fasting plasma TMAO was measured by mass spectrometry.Results: The proportion of frail subjects was 29.9% (135/451). Plasma TMAO levels were significantly higher in frail patients than in nonfrail individuals (4.04 [2.84– 7.01] vs 3.21 [2.13– 5.03] μM; p< 0.001). Elevated plasma TMAO levels were independently associated with the likelihood of frailty (OR 2.12, 95% CI 1.01– 4.38, p=0.046). Dose–response analysis revealed a linear association between the TMAO concentration and the OR for frailty. A 2-unit increase in TMAO was independently correlated with physical frailty (OR 1.23, 95% CI 1.08– 1.41, p for trend 0.002) and cognitive frailty (OR 1.21, 95% CI 1.01– 1.45, p for trend 0.04).Conclusion: Elevated circulating TMAO levels are independently associated with frailty among older adults with cardiovascular disease.Keywords: older adults, frailty, TMAO, cardiovascular disease, physical frailty, cognitive frailtyhttps://www.dovepress.com/trimethylamine-n-oxide-a-gut-microbiota-dependent-metabolite-is-associ-peer-reviewed-article-CIAolder adultsfrailtytmaocardiovascular diseasephysical frailtycognitive frailty |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
He W Luo Y Liu JP Sun N Guo D Cui LL Zheng PP Yao SM Yang JF Wang H |
spellingShingle |
He W Luo Y Liu JP Sun N Guo D Cui LL Zheng PP Yao SM Yang JF Wang H Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease Clinical Interventions in Aging older adults frailty tmao cardiovascular disease physical frailty cognitive frailty |
author_facet |
He W Luo Y Liu JP Sun N Guo D Cui LL Zheng PP Yao SM Yang JF Wang H |
author_sort |
He W |
title |
Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease |
title_short |
Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease |
title_full |
Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease |
title_fullStr |
Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease |
title_full_unstemmed |
Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease |
title_sort |
trimethylamine n-oxide, a gut microbiota-dependent metabolite, is associated with frailty in older adults with cardiovascular disease |
publisher |
Dove Medical Press |
series |
Clinical Interventions in Aging |
issn |
1178-1998 |
publishDate |
2020-09-01 |
description |
Wei He,1,2 Yao Luo,1 Jun-Peng Liu,1 Ning Sun,1 Di Guo,1 Ling-Ling Cui,1 Pei-Pei Zheng,1 Si-Min Yao,1 Jie-Fu Yang,1,2 Hua Wang1,2 1Department of Cardiology, Beijing Hospital, National Center of Gerontology, Beijing, People’s Republic of China; 2Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Hua Wang; Jie-Fu YangDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, No. 1, Dahua Road, Dongcheng District, Beijing 100730, People’s Republic of ChinaTel +86 13911680467; +86 13601292259Fax +86 10-58115035Email wanghua2764@bjhmoh.cn; yangjiefu2011@126.comObjective: Our study aimed to explore the association between trimethylamine N-oxide and frailty in older adults with cardiovascular disease.Patients and Methods: This cross-sectional study analyzed a total of 451 people aged 65 years or older who underwent comprehensive geriatric assessments. Frailty status was determined using a frailty index constructed with 48 variables according to the cumulative deficits model. Physical frailty and cognitive frailty were also assessed in detail. Fasting plasma TMAO was measured by mass spectrometry.Results: The proportion of frail subjects was 29.9% (135/451). Plasma TMAO levels were significantly higher in frail patients than in nonfrail individuals (4.04 [2.84– 7.01] vs 3.21 [2.13– 5.03] μM; p< 0.001). Elevated plasma TMAO levels were independently associated with the likelihood of frailty (OR 2.12, 95% CI 1.01– 4.38, p=0.046). Dose–response analysis revealed a linear association between the TMAO concentration and the OR for frailty. A 2-unit increase in TMAO was independently correlated with physical frailty (OR 1.23, 95% CI 1.08– 1.41, p for trend 0.002) and cognitive frailty (OR 1.21, 95% CI 1.01– 1.45, p for trend 0.04).Conclusion: Elevated circulating TMAO levels are independently associated with frailty among older adults with cardiovascular disease.Keywords: older adults, frailty, TMAO, cardiovascular disease, physical frailty, cognitive frailty |
topic |
older adults frailty tmao cardiovascular disease physical frailty cognitive frailty |
url |
https://www.dovepress.com/trimethylamine-n-oxide-a-gut-microbiota-dependent-metabolite-is-associ-peer-reviewed-article-CIA |
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