Prognostic risk factors in patients with hepatitis B virus-related acute-on-chronic liver failure
ObjectiveTo investigate the clinical characteristic and long-term prognosis risk factor of patients with hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF). MethodsThe clinical data of 1116 HBV-ACLF patients who were hospitalized in Southwest Hospital of Third Military Medical Univer...
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Editorial Department of Journal of Clinical Hepatology
2016-04-01
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doaj-db4a2169f9e646b6be4c6fe0323e22102020-11-24T22:09:48ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562016-04-0132470070510.3969/j.issn.1001-5256.2016.04.018Prognostic risk factors in patients with hepatitis B virus-related acute-on-chronic liver failure SHI Xinxing0ZHANG Yanqiong1ZHU Peng2Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, ChinaDepartment of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, ChinaDepartment of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, ChinaObjectiveTo investigate the clinical characteristic and long-term prognosis risk factor of patients with hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF). MethodsThe clinical data of 1116 HBV-ACLF patients who were hospitalized in Southwest Hospital of Third Military Medical University from January 2010 to January 2015 were analyzed retrospectively. The risk factors for 1-year survival time and prognosis were observed, and the Cox regression model was used to determine the independent risk factors for the prognosis of these patients. The t-test or t′-test was applied for comparison of continuous data between groups, and the chi-square test was applied for comparison of categorical data between groups. ResultsA total of 562 patients died within the 1-year follow-up period, and the fatality rate was 50.4%. The comparison between the survival group and the death group showed that age, alanine aminotransferase, total bilirubin, urea nitrogen, serum creatinine, international normalized ratio, serum Na+, white blood cell (WBC), percentage of neutrophils, platelet (PLT), HBV DNA load, Model for End-Stage Liver Disease (MELD) score, ascites, spontaneous bacterial peritonitis, gastrointestinal bleeding, pulmonary infection, sepsis, electrolyte disturbance, hepatic encephalopathy, and acute kidney injury (AKI) were the risk factors for death within 1 year (all P<0.05). The Cox regression analysis showed that age, WBC, MELD score, hepatic encephalopathy, electrolyte disturbance, AKI, and PLT were the independent risk factors for the 1-year fatality in HBV-ACLF patients (all P<0.05). ConclusionOur findings show that HBV-ACLF has a high fatality rate and is often accompanied by serious complications. The major risk factors affecting the 1-year fatality in HBV-ACLF patients are age, WBC, MELD score, hepatic encephalopathy, electrolyte disturbance, AKI, and PLT. http://www.lcgdbzz.org/qk_content.asp?id=7299 |
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DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
SHI Xinxing ZHANG Yanqiong ZHU Peng |
spellingShingle |
SHI Xinxing ZHANG Yanqiong ZHU Peng Prognostic risk factors in patients with hepatitis B virus-related acute-on-chronic liver failure Linchuang Gandanbing Zazhi |
author_facet |
SHI Xinxing ZHANG Yanqiong ZHU Peng |
author_sort |
SHI Xinxing |
title |
Prognostic risk factors in patients with hepatitis B virus-related acute-on-chronic liver failure |
title_short |
Prognostic risk factors in patients with hepatitis B virus-related acute-on-chronic liver failure |
title_full |
Prognostic risk factors in patients with hepatitis B virus-related acute-on-chronic liver failure |
title_fullStr |
Prognostic risk factors in patients with hepatitis B virus-related acute-on-chronic liver failure |
title_full_unstemmed |
Prognostic risk factors in patients with hepatitis B virus-related acute-on-chronic liver failure |
title_sort |
prognostic risk factors in patients with hepatitis b virus-related acute-on-chronic liver failure |
publisher |
Editorial Department of Journal of Clinical Hepatology |
series |
Linchuang Gandanbing Zazhi |
issn |
1001-5256 1001-5256 |
publishDate |
2016-04-01 |
description |
ObjectiveTo investigate the clinical characteristic and long-term prognosis risk factor of patients with hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF). MethodsThe clinical data of 1116 HBV-ACLF patients who were hospitalized in Southwest Hospital of Third Military Medical University from January 2010 to January 2015 were analyzed retrospectively. The risk factors for 1-year survival time and prognosis were observed, and the Cox regression model was used to determine the independent risk factors for the prognosis of these patients. The t-test or t′-test was applied for comparison of continuous data between groups, and the chi-square test was applied for comparison of categorical data between groups. ResultsA total of 562 patients died within the 1-year follow-up period, and the fatality rate was 50.4%. The comparison between the survival group and the death group showed that age, alanine aminotransferase, total bilirubin, urea nitrogen, serum creatinine, international normalized ratio, serum Na+, white blood cell (WBC), percentage of neutrophils, platelet (PLT), HBV DNA load, Model for End-Stage Liver Disease (MELD) score, ascites, spontaneous bacterial peritonitis, gastrointestinal bleeding, pulmonary infection, sepsis, electrolyte disturbance, hepatic encephalopathy, and acute kidney injury (AKI) were the risk factors for death within 1 year (all P<0.05). The Cox regression analysis showed that age, WBC, MELD score, hepatic encephalopathy, electrolyte disturbance, AKI, and PLT were the independent risk factors for the 1-year fatality in HBV-ACLF patients (all P<0.05). ConclusionOur findings show that HBV-ACLF has a high fatality rate and is often accompanied by serious complications. The major risk factors affecting the 1-year fatality in HBV-ACLF patients are age, WBC, MELD score, hepatic encephalopathy, electrolyte disturbance, AKI, and PLT. |
url |
http://www.lcgdbzz.org/qk_content.asp?id=7299 |
work_keys_str_mv |
AT shixinxing prognosticriskfactorsinpatientswithhepatitisbvirusrelatedacuteonchronicliverfailure AT zhangyanqiong prognosticriskfactorsinpatientswithhepatitisbvirusrelatedacuteonchronicliverfailure AT zhupeng prognosticriskfactorsinpatientswithhepatitisbvirusrelatedacuteonchronicliverfailure |
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1725810616241750016 |