Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco
Abstract Background Toxoplasmosis is an infectious disease caused by a protozoan parasite named Toxoplasma gondii (T.gondii). Pregnant women are considered one of the risk groups. The objective of this retrospective study is to provide an updated estimate of the seroprevalence of anti-T. gondii anti...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-03-01
|
Series: | Tropical Medicine and Health |
Subjects: | |
Online Access: | https://doi.org/10.1186/s41182-021-00311-5 |
id |
doaj-db51ddfe8a4042ceb533fe0eda2112b4 |
---|---|
record_format |
Article |
spelling |
doaj-db51ddfe8a4042ceb533fe0eda2112b42021-03-11T12:06:27ZengBMCTropical Medicine and Health1349-41472021-03-014911810.1186/s41182-021-00311-5Toxoplasma gondii seroprevalence among pregnant women in Rabat, MoroccoMajda Laboudi0Zoubida Taghy1Oussama Duieb2François Peyron3Abderrahim Sadak4Department of Parasitology, National Institute of HygieneFaculty of Science, University Mohamed VFaculty of Science, University Mohamed VInstitut de Parasitologie et de Mycologie Médicale Hôpital de la Croix RousseFaculty of Science, University Mohamed VAbstract Background Toxoplasmosis is an infectious disease caused by a protozoan parasite named Toxoplasma gondii (T.gondii). Pregnant women are considered one of the risk groups. The objective of this retrospective study is to provide an updated estimate of the seroprevalence of anti-T. gondii antibodies among a group of Moroccan pregnant women monitored at the Parasitology Laboratory of the National Institute of Hygiene in Rabat in Morocco. Methods Serum samples were tested for the presence of specific anti-T. gondii immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies using indirect enzyme-linked immunosorbent assay (ELISA). Anti-Toxoplasma IgM- and IgG-positive cases were also evaluated with the anti-Toxoplasma IgG avidity test. All cases were evaluated according to the age, parity, and historical of abortion. Results Among 677 pregnant women, 94.1% (637/677) were serologically screened for the first time and therefore had no knowledge of their serological status, and only 5.9% (40/677) were screened for the second or third time. The overall anti-T. gondii IgG and IgM seropositivity among the 637 pregnant women included in the study analysis was 43% (274/637) and 3.9% (25/637), respectively. The use of the IgG avidity test allowed excluding recent infection among 83% of cases with IgG and IgM positive sera. The mean age was 29.4 ± 6.3 years. The result of the bivariate analysis revealed that the age influenced significantly the seroprevalence rate, while the parity and the existence of previous spontaneous abortion did not have any significant statistical correlation with seropositivity to T. gondii. Conclusion This study shows that 43% of pregnant women were positive and 57% of them had no antibody against the T. gondii infection. However, the pregnancy follow-up and the counseling of pregnant women remain essential for the prevention of congenital toxoplasmosis.https://doi.org/10.1186/s41182-021-00311-5ToxoplasmosisToxoplasma gondiiPregnant womenPrevalenceRabatMorocco |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Majda Laboudi Zoubida Taghy Oussama Duieb François Peyron Abderrahim Sadak |
spellingShingle |
Majda Laboudi Zoubida Taghy Oussama Duieb François Peyron Abderrahim Sadak Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco Tropical Medicine and Health Toxoplasmosis Toxoplasma gondii Pregnant women Prevalence Rabat Morocco |
author_facet |
Majda Laboudi Zoubida Taghy Oussama Duieb François Peyron Abderrahim Sadak |
author_sort |
Majda Laboudi |
title |
Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco |
title_short |
Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco |
title_full |
Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco |
title_fullStr |
Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco |
title_full_unstemmed |
Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco |
title_sort |
toxoplasma gondii seroprevalence among pregnant women in rabat, morocco |
publisher |
BMC |
series |
Tropical Medicine and Health |
issn |
1349-4147 |
publishDate |
2021-03-01 |
description |
Abstract Background Toxoplasmosis is an infectious disease caused by a protozoan parasite named Toxoplasma gondii (T.gondii). Pregnant women are considered one of the risk groups. The objective of this retrospective study is to provide an updated estimate of the seroprevalence of anti-T. gondii antibodies among a group of Moroccan pregnant women monitored at the Parasitology Laboratory of the National Institute of Hygiene in Rabat in Morocco. Methods Serum samples were tested for the presence of specific anti-T. gondii immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies using indirect enzyme-linked immunosorbent assay (ELISA). Anti-Toxoplasma IgM- and IgG-positive cases were also evaluated with the anti-Toxoplasma IgG avidity test. All cases were evaluated according to the age, parity, and historical of abortion. Results Among 677 pregnant women, 94.1% (637/677) were serologically screened for the first time and therefore had no knowledge of their serological status, and only 5.9% (40/677) were screened for the second or third time. The overall anti-T. gondii IgG and IgM seropositivity among the 637 pregnant women included in the study analysis was 43% (274/637) and 3.9% (25/637), respectively. The use of the IgG avidity test allowed excluding recent infection among 83% of cases with IgG and IgM positive sera. The mean age was 29.4 ± 6.3 years. The result of the bivariate analysis revealed that the age influenced significantly the seroprevalence rate, while the parity and the existence of previous spontaneous abortion did not have any significant statistical correlation with seropositivity to T. gondii. Conclusion This study shows that 43% of pregnant women were positive and 57% of them had no antibody against the T. gondii infection. However, the pregnancy follow-up and the counseling of pregnant women remain essential for the prevention of congenital toxoplasmosis. |
topic |
Toxoplasmosis Toxoplasma gondii Pregnant women Prevalence Rabat Morocco |
url |
https://doi.org/10.1186/s41182-021-00311-5 |
work_keys_str_mv |
AT majdalaboudi toxoplasmagondiiseroprevalenceamongpregnantwomeninrabatmorocco AT zoubidataghy toxoplasmagondiiseroprevalenceamongpregnantwomeninrabatmorocco AT oussamaduieb toxoplasmagondiiseroprevalenceamongpregnantwomeninrabatmorocco AT francoispeyron toxoplasmagondiiseroprevalenceamongpregnantwomeninrabatmorocco AT abderrahimsadak toxoplasmagondiiseroprevalenceamongpregnantwomeninrabatmorocco |
_version_ |
1724224897715011584 |