The prevalence of circulating S. pneumoniae serotypes in people older than 18 years: healthy carriers, patients with acute otitis media, community-acquired pneumonia, and invasive pneumococcal infections (epidemiological study «SPECTRUM»)
Objective. To estimate the prevalence of S. pneumoniae serotypes in adults aged of 18 years and older, including healthy carriers and patients with acute otitis media (AOM), community-acquired pneumonia (CAP) and invasive pneumococcal infection (IPI). Materials and Methods. A total of 230 isolat...
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Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
2019-12-01
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Online Access: | https://cmac-journal.ru/publication/2019/4/cmac-2019-t21-n4-p275/cmac-2019-t21-n4-p275.pdf |
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doaj-db56a513a48b445cb785bebec36a1c5c2020-11-25T02:02:53ZrusInterregional Association for Clinical Microbiology and Antimicrobial ChemotherapyКлиническая микробиология и антимикробная химиотерапия1684-43862686-95862019-12-0121427528110.36488/cmac.2019.4.275-281cmac-2019-t21-n4-p275The prevalence of circulating S. pneumoniae serotypes in people older than 18 years: healthy carriers, patients with acute otitis media, community-acquired pneumonia, and invasive pneumococcal infections (epidemiological study «SPECTRUM»)Muravyev A.A.0Chagaryan A.N.1Ivanchik N.V.2Kurkova A.A.3Tsvetkova I.A.4Kozlov R.S.5Morozova O.A.6Kirillova G.SH.7Popova L.D.8Moskvitina E.N.9Petrova T.A.10Martyanova N.M.11Ershova M.G.12Bykonya S.A.13Institute of Antimicrobial Chemotherapy, Smolensk, RussiaInstitute of Antimicrobial Chemotherapy, Smolensk, RussiaInstitute of Antimicrobial Chemotherapy, Smolensk, RussiaInstitute of Antimicrobial Chemotherapy, Smolensk, RussiaChildren Scientific Clinical Center of Infectious Diseases, Saint-Petersburg, RussiaInstitute of Antimicrobial Chemotherapy, Smolensk, RussiaFGAOU VO «Pervyj MGMU im. I.M. Sechenova» Minzdrava Rossii, MoscowGAUZ RT «BSMP», KazanBUZOO «OKB», OmskFGBU «SibFNKC» FMBA Rossii, SeverskOGBUZ «KB №1», SmolenskGBUZ SO «TGKB №5», TolyattiGBUZ YAO «IKB №1», YaroslavlOGAUZ «TOKB», TomskObjective. To estimate the prevalence of S. pneumoniae serotypes in adults aged of 18 years and older, including healthy carriers and patients with acute otitis media (AOM), community-acquired pneumonia (CAP) and invasive pneumococcal infection (IPI). Materials and Methods. A total of 230 isolates of S. pneumoniae from 10 centers were included in the study from 01.06.2019 to 01.10.2019. Re-identification and typing using real-time PCR with 22 primer pairs were performed in the central laboratory (Institute of Antimicrobial Chemotherapy, Russia). Results. In healthy nasopharyngeal carriers (n = 31), the following serotypes of S. pneumoniae were detected: 19F (29.0%), 6А/В (22.6%), 3 (16.1%), 11A/D and 23F (9.7% each), 23A (6.4%), 14 and 15A/F (3.2% each); PCV-13 and PPV-23 covered 80.6% and 90.3% of those serotypes, respectively. In patients with AOM (n = 18), serotypes were: 3 (16.7%), 11A/D and 6A/B (11.1%, each), 16, 19А, 19F, 23F, 7A/F (5.55%, each); PCV-13 and PPV-23 covered 50% and 61.1% of those serotypes, respectively. Among 166 isolates from patients with CAP, the following serotypes were detected: 3 (12.0%), 19F and 6A/B (10.2%, each), 14 and 11A/D (5.4% each), 15A/F and 23A (4.8% each), 9N/L (4.2%), 18 and 22A/F (2.4% each), 19A and 23F (1.8% each), 16, 9V/A (1.2% each), 4 and 33A/33F/37 (0.6% each), non-vaccine serotypes (30.3%); PCV-13 and PPV-23 covered 45.6% and 57.0% of those serotypes, respectively. Isolates from patients with IPI (n=15) belonged to the following serotypes: 3 (26.7%), 12F, 23F and 9N/L (13.3% each), serotypes 4 and 15A/F (6.7%), non-vaccine serotype – 1 isolate (6.7%); PCV-13 and PPV-23 covered 46.7% and 73.3% of those serotypes, respectively. Conclusions. The majority of S. pneumoniae serotypes in adult population in Russia are included in PPV-23, but not in PCV-13 (primarily due to serotype 11A/D). There was a high PCV-13 and PPV-23 coverage of serotypes from healthy nasopharyngeal carriers. PPV-23 covered more than 60% of clinical isolates, whereas PCV-13 covered less than 60% (AOM – 50.0%, CAP – 45.6%, IPI – 46.7%), thus indicating a potentially lower efficacy of PCV-13 in adult population.https://cmac-journal.ru/publication/2019/4/cmac-2019-t21-n4-p275/cmac-2019-t21-n4-p275.pdfs pneumoniaeserotypesepidemiologyhealthy carriageacute otitis mediapneumoniainvasive pneumococcal infection |
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DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
Muravyev A.A. Chagaryan A.N. Ivanchik N.V. Kurkova A.A. Tsvetkova I.A. Kozlov R.S. Morozova O.A. Kirillova G.SH. Popova L.D. Moskvitina E.N. Petrova T.A. Martyanova N.M. Ershova M.G. Bykonya S.A. |
spellingShingle |
Muravyev A.A. Chagaryan A.N. Ivanchik N.V. Kurkova A.A. Tsvetkova I.A. Kozlov R.S. Morozova O.A. Kirillova G.SH. Popova L.D. Moskvitina E.N. Petrova T.A. Martyanova N.M. Ershova M.G. Bykonya S.A. The prevalence of circulating S. pneumoniae serotypes in people older than 18 years: healthy carriers, patients with acute otitis media, community-acquired pneumonia, and invasive pneumococcal infections (epidemiological study «SPECTRUM») Клиническая микробиология и антимикробная химиотерапия s pneumoniae serotypes epidemiology healthy carriage acute otitis media pneumonia invasive pneumococcal infection |
author_facet |
Muravyev A.A. Chagaryan A.N. Ivanchik N.V. Kurkova A.A. Tsvetkova I.A. Kozlov R.S. Morozova O.A. Kirillova G.SH. Popova L.D. Moskvitina E.N. Petrova T.A. Martyanova N.M. Ershova M.G. Bykonya S.A. |
author_sort |
Muravyev A.A. |
title |
The prevalence of circulating S. pneumoniae serotypes in people older than 18 years: healthy carriers, patients with acute otitis media, community-acquired pneumonia, and invasive pneumococcal infections (epidemiological study «SPECTRUM») |
title_short |
The prevalence of circulating S. pneumoniae serotypes in people older than 18 years: healthy carriers, patients with acute otitis media, community-acquired pneumonia, and invasive pneumococcal infections (epidemiological study «SPECTRUM») |
title_full |
The prevalence of circulating S. pneumoniae serotypes in people older than 18 years: healthy carriers, patients with acute otitis media, community-acquired pneumonia, and invasive pneumococcal infections (epidemiological study «SPECTRUM») |
title_fullStr |
The prevalence of circulating S. pneumoniae serotypes in people older than 18 years: healthy carriers, patients with acute otitis media, community-acquired pneumonia, and invasive pneumococcal infections (epidemiological study «SPECTRUM») |
title_full_unstemmed |
The prevalence of circulating S. pneumoniae serotypes in people older than 18 years: healthy carriers, patients with acute otitis media, community-acquired pneumonia, and invasive pneumococcal infections (epidemiological study «SPECTRUM») |
title_sort |
prevalence of circulating s. pneumoniae serotypes in people older than 18 years: healthy carriers, patients with acute otitis media, community-acquired pneumonia, and invasive pneumococcal infections (epidemiological study «spectrum») |
publisher |
Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy |
series |
Клиническая микробиология и антимикробная химиотерапия |
issn |
1684-4386 2686-9586 |
publishDate |
2019-12-01 |
description |
Objective.
To estimate the prevalence of S. pneumoniae serotypes in adults aged of 18 years and older, including healthy carriers and patients with acute otitis media (AOM), community-acquired pneumonia (CAP) and invasive pneumococcal infection (IPI).
Materials and Methods.
A total of 230 isolates of S. pneumoniae from 10 centers were included in the study from 01.06.2019 to 01.10.2019. Re-identification and typing using real-time PCR with 22 primer pairs were performed in the central laboratory (Institute of Antimicrobial Chemotherapy, Russia).
Results.
In healthy nasopharyngeal carriers (n = 31), the following serotypes of S. pneumoniae were detected: 19F (29.0%), 6А/В (22.6%), 3 (16.1%), 11A/D and 23F (9.7% each), 23A (6.4%), 14 and 15A/F (3.2% each); PCV-13 and PPV-23 covered 80.6% and 90.3% of those serotypes, respectively. In patients with AOM (n = 18), serotypes were: 3 (16.7%), 11A/D and 6A/B (11.1%, each), 16, 19А, 19F, 23F, 7A/F (5.55%, each); PCV-13 and PPV-23 covered 50% and 61.1% of those serotypes, respectively. Among 166 isolates from patients with CAP, the following serotypes were detected: 3 (12.0%), 19F and 6A/B (10.2%, each), 14 and 11A/D (5.4% each), 15A/F and 23A (4.8% each), 9N/L (4.2%), 18 and 22A/F (2.4% each), 19A and 23F (1.8% each), 16, 9V/A (1.2% each), 4 and 33A/33F/37 (0.6% each), non-vaccine serotypes (30.3%); PCV-13 and PPV-23 covered 45.6% and 57.0% of those serotypes, respectively. Isolates from patients with IPI (n=15) belonged to the following serotypes: 3 (26.7%), 12F, 23F and 9N/L (13.3% each), serotypes 4 and 15A/F (6.7%), non-vaccine serotype – 1 isolate (6.7%); PCV-13 and PPV-23 covered 46.7% and 73.3% of those serotypes, respectively.
Conclusions.
The majority of S. pneumoniae serotypes in adult population in Russia are included in PPV-23, but not in PCV-13 (primarily due to serotype 11A/D). There was a high PCV-13 and PPV-23 coverage of serotypes from healthy nasopharyngeal carriers. PPV-23 covered more than 60% of clinical isolates, whereas PCV-13 covered less than 60% (AOM – 50.0%, CAP – 45.6%, IPI – 46.7%), thus indicating a potentially lower efficacy of PCV-13 in adult population. |
topic |
s pneumoniae serotypes epidemiology healthy carriage acute otitis media pneumonia invasive pneumococcal infection |
url |
https://cmac-journal.ru/publication/2019/4/cmac-2019-t21-n4-p275/cmac-2019-t21-n4-p275.pdf |
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