Pre-pregnancy BMI, gestational weight gain and risk of preeclampsia: a birth cohort study in Lanzhou, China
Abstract Background To evaluate the independent and joint effects of maternal pre-pregnancy BMI and gestational weight gain (GWG) on the risk of preeclampsia and its subtypes. Methods A birth cohort study was conducted from 2010 to 2012 in Lanzhou, China. Three hundred fourty seven pregnant women wi...
Main Authors: | , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-12-01
|
Series: | BMC Pregnancy and Childbirth |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12884-017-1567-2 |
id |
doaj-db5d0e05c8ad4da7add36cf36a3b5416 |
---|---|
record_format |
Article |
spelling |
doaj-db5d0e05c8ad4da7add36cf36a3b54162020-11-24T23:04:22ZengBMCBMC Pregnancy and Childbirth1471-23932017-12-011711810.1186/s12884-017-1567-2Pre-pregnancy BMI, gestational weight gain and risk of preeclampsia: a birth cohort study in Lanzhou, ChinaYawen Shao0Jie Qiu1Huang Huang2Baohong Mao3Wei Dai4Xiaochun He5Hongmei Cui6Xiaojuan Lin7Ling Lv8Dennis Wang9Zhongfeng Tang10Sijuan Xu11Nan Zhao12Min Zhou13Xiaoying Xu14Weitao Qiu15Qing Liu16Yawei Zhang17Gansu Provincial Maternity and Child Care HospitalGansu Provincial Maternity and Child Care HospitalYale University School of Public HealthGansu Provincial Maternity and Child Care HospitalGansu Provincial Maternity and Child Care HospitalGansu Provincial Maternity and Child Care HospitalGansu Provincial Maternity and Child Care HospitalGansu Provincial Maternity and Child Care HospitalGansu Provincial Maternity and Child Care HospitalYale University School of Public HealthGansu Provincial Maternity and Child Care HospitalGansu Provincial Maternity and Child Care HospitalYale University School of Public HealthGansu Provincial Maternity and Child Care HospitalGansu Provincial Maternity and Child Care HospitalGansu Provincial Maternity and Child Care HospitalGansu Provincial Maternity and Child Care HospitalYale University School of Public HealthAbstract Background To evaluate the independent and joint effects of maternal pre-pregnancy BMI and gestational weight gain (GWG) on the risk of preeclampsia and its subtypes. Methods A birth cohort study was conducted from 2010 to 2012 in Lanzhou, China. Three hundred fourty seven pregnant women with preeclampsia and 9516 normotensive women at Gansu Provincial Maternity and Child Care Hospital were included in the present study. Unconditional logistic regression models were used to evaluate the associations between pre-pregnancy BMI, GWG, and risk of preeclampsia and its subtypes. Results Compared to women with normal pre-pregnancy BMI, those who were overweight/obese had an increased risk of preeclampsia (OR = 1.81; 95%CI: 1.37–2.39). Women with excessive GWG had an increased risk of preeclampsia (OR = 2.28; 95%CI: 1.70–3.05) compared to women with adequate GWG. The observed increased risk was similar for mild-, severe- and late-onset preeclampsia. No association was found for early-onset preeclampsia. Overweight/obese women with excessive GWG had the highest risk of developing preeclampsia compared to normal weight women with no excessive weight gain (OR = 3.78; 95%CI: 2.65–5.41). Conclusions Our results suggested that pre-pregnancy BMI and GWG are independent risk factors for preeclampsia and that the risk might vary by preeclampsia subtypes. Our study also proposed a potential synergistic effect of pre-pregnancy BMI and GWG that warrants further investigation.http://link.springer.com/article/10.1186/s12884-017-1567-2Pre-pregnancy BMIGestational weight gainPreeclampsiaChinaBirth cohort |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yawen Shao Jie Qiu Huang Huang Baohong Mao Wei Dai Xiaochun He Hongmei Cui Xiaojuan Lin Ling Lv Dennis Wang Zhongfeng Tang Sijuan Xu Nan Zhao Min Zhou Xiaoying Xu Weitao Qiu Qing Liu Yawei Zhang |
spellingShingle |
Yawen Shao Jie Qiu Huang Huang Baohong Mao Wei Dai Xiaochun He Hongmei Cui Xiaojuan Lin Ling Lv Dennis Wang Zhongfeng Tang Sijuan Xu Nan Zhao Min Zhou Xiaoying Xu Weitao Qiu Qing Liu Yawei Zhang Pre-pregnancy BMI, gestational weight gain and risk of preeclampsia: a birth cohort study in Lanzhou, China BMC Pregnancy and Childbirth Pre-pregnancy BMI Gestational weight gain Preeclampsia China Birth cohort |
author_facet |
Yawen Shao Jie Qiu Huang Huang Baohong Mao Wei Dai Xiaochun He Hongmei Cui Xiaojuan Lin Ling Lv Dennis Wang Zhongfeng Tang Sijuan Xu Nan Zhao Min Zhou Xiaoying Xu Weitao Qiu Qing Liu Yawei Zhang |
author_sort |
Yawen Shao |
title |
Pre-pregnancy BMI, gestational weight gain and risk of preeclampsia: a birth cohort study in Lanzhou, China |
title_short |
Pre-pregnancy BMI, gestational weight gain and risk of preeclampsia: a birth cohort study in Lanzhou, China |
title_full |
Pre-pregnancy BMI, gestational weight gain and risk of preeclampsia: a birth cohort study in Lanzhou, China |
title_fullStr |
Pre-pregnancy BMI, gestational weight gain and risk of preeclampsia: a birth cohort study in Lanzhou, China |
title_full_unstemmed |
Pre-pregnancy BMI, gestational weight gain and risk of preeclampsia: a birth cohort study in Lanzhou, China |
title_sort |
pre-pregnancy bmi, gestational weight gain and risk of preeclampsia: a birth cohort study in lanzhou, china |
publisher |
BMC |
series |
BMC Pregnancy and Childbirth |
issn |
1471-2393 |
publishDate |
2017-12-01 |
description |
Abstract Background To evaluate the independent and joint effects of maternal pre-pregnancy BMI and gestational weight gain (GWG) on the risk of preeclampsia and its subtypes. Methods A birth cohort study was conducted from 2010 to 2012 in Lanzhou, China. Three hundred fourty seven pregnant women with preeclampsia and 9516 normotensive women at Gansu Provincial Maternity and Child Care Hospital were included in the present study. Unconditional logistic regression models were used to evaluate the associations between pre-pregnancy BMI, GWG, and risk of preeclampsia and its subtypes. Results Compared to women with normal pre-pregnancy BMI, those who were overweight/obese had an increased risk of preeclampsia (OR = 1.81; 95%CI: 1.37–2.39). Women with excessive GWG had an increased risk of preeclampsia (OR = 2.28; 95%CI: 1.70–3.05) compared to women with adequate GWG. The observed increased risk was similar for mild-, severe- and late-onset preeclampsia. No association was found for early-onset preeclampsia. Overweight/obese women with excessive GWG had the highest risk of developing preeclampsia compared to normal weight women with no excessive weight gain (OR = 3.78; 95%CI: 2.65–5.41). Conclusions Our results suggested that pre-pregnancy BMI and GWG are independent risk factors for preeclampsia and that the risk might vary by preeclampsia subtypes. Our study also proposed a potential synergistic effect of pre-pregnancy BMI and GWG that warrants further investigation. |
topic |
Pre-pregnancy BMI Gestational weight gain Preeclampsia China Birth cohort |
url |
http://link.springer.com/article/10.1186/s12884-017-1567-2 |
work_keys_str_mv |
AT yawenshao prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT jieqiu prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT huanghuang prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT baohongmao prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT weidai prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT xiaochunhe prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT hongmeicui prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT xiaojuanlin prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT linglv prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT denniswang prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT zhongfengtang prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT sijuanxu prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT nanzhao prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT minzhou prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT xiaoyingxu prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT weitaoqiu prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT qingliu prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina AT yaweizhang prepregnancybmigestationalweightgainandriskofpreeclampsiaabirthcohortstudyinlanzhouchina |
_version_ |
1725630925317865472 |