ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels

ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels

The neuronal voltage-gated N-type calcium channel (Cav2.2) is a validated target for the treatment of neuropathic pain. A small library of anthranilamide-derived ω-Conotoxin GVIA mimetics bearing the diphenylmethylpiperazine moiety were prepared and tested using three experimental measures of calciu...

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Bibliographic Details
Main Authors: Peter J. Duggan, Aijun Yang, Irina Vetter, Jeffrey R. McArthur, Richard J. Lewis, Kellie L. Tuck, Jonathan B. Baell, Charlotte Elisabet Tranberg
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:Marine Drugs
Subjects:
Cav2.2
conotoxin
peptidomimetics
radioligand binding
Ca2+ fluorescence assay
patch clamp electrophysiology
Online Access:http://www.mdpi.com/1660-3397/10/10/2349

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