Tumor Signature Analysis Implicates Hereditary Cancer Genes in Endometrial Cancer Development

Tumor Signature Analysis Implicates Hereditary Cancer Genes in Endometrial Cancer Development

Risk of endometrial cancer (EC) is increased ~2-fold for women with a family history of cancer, partly due to inherited pathogenic variants in mismatch repair (MMR) genes. We explored the role of additional genes as explanation for familial EC presentation by investigating germline and EC tumor sequ...

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Bibliographic Details
Main Authors: Olga Kondrashova, Jannah Shamsani, Tracy A. O’Mara, Felicity Newell, Amy E. McCart Reed, Sunil R. Lakhani, Judy Kirk, John V. Pearson, Nicola Waddell, Amanda B. Spurdle
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
endometrial cancer
genomic sequencing
tumor mutational signatures
hereditary cancer genes
mismatch repair
familial cancer
Online Access:https://www.mdpi.com/2072-6694/13/8/1762

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