Asiatic Acid Induces Endoplasmic Reticulum Stress and Activates the Grp78/IRE1α/JNK and Calpain Pathways to Inhibit Tongue Cancer Growth
Asiatic acid (AA) has been shown to induce apoptotic death in a range of cancers, but the mechanisms whereby it can inhibit tongue cancer growth have yet to be clarified. Herein, we explored the effects of AA on tongue cancer cells and found that it induced their apoptotic death in vitro and in vivo...
Main Authors: | Jialin Li, Kan Chen, Jianhua Huang, Dongqing Chu, Miaomiao Tian, Keqiang Huang, Chunyu Ma |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-05-01
|
Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.690612/full |
Similar Items
-
Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways
by: Dalia O. Saleh, et al.
Published: (2020-01-01) -
Upregulation of Phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in Acquired Middle Ear Cholesteatoma Growth
by: Kuen Yao Ho, et al.
Published: (2013-07-01) -
Co-downregulation of GRP78 and GRP94 induces apoptosis and inhibits migration in prostate cancer cells
by: Lu Tong, et al.
Published: (2019-07-01) -
GRP78 and endoplasmic reticulum stress in endometrial cancer
by: Luca eUlianich, et al.
Published: (2014-12-01) -
Significance of GRP78 expression in acute myeloid leukemias
by: Wróbel Tomasz, et al.
Published: (2014-04-01)