Silencing of <i>Sphingosine kinase 1</i> Affects Maturation Pathways in Mouse Neonatal Cardiomyocytes

Silencing of <i>Sphingosine kinase 1</i> Affects Maturation Pathways in Mouse Neonatal Cardiomyocytes

Sphingosine kinase-1 (Sphk1) and its product, sphingosine-1-phosphate (S1P) are important regulators of cardiac growth and function. Numerous studies have reported that Sphk1/S1P signaling is essential for embryonic cardiac development and promotes pathological cardiac hypertrophy in adulthood. Howe...

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Bibliographic Details
Main Authors: Ewelina Jozefczuk, Piotr Szczepaniak, Tomasz Jan Guzik, Mateusz Siedlinski
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
sphingosine kinase-1
sphingosine-1-phosphate
cardiomyocyte
cardiomyocyte hypertrophy
cardiomyocyte maturation
cardiomyocyte proliferation
Online Access:https://www.mdpi.com/1422-0067/22/7/3616

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