Bioavailability of VEGF in Tumor-Shed Vesicles Depends on Vesicle Burst Induced by Acidic pH

Bioavailability of VEGF in Tumor-Shed Vesicles Depends on Vesicle Burst Induced by Acidic pH

Tumor angiogenesis is regulated by a dynamic crosstalk between tumor cells and the host microenvironment. Because membrane vesicles shed by tumor cells are known to mediate several tumor—host interactions, we determined whether vesicles might also stimulate angiogenesis. Vesicles shed by human ovar...

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Bibliographic Details
Main Authors: Giulia Taraboletti, Sandra D'Ascenzoy, Ilaria Giusti, Daniela Marchetti, Patrizia Borsotti, Danilo Millimaggi, Raffaella Giavazzi, Antonio Pavan, Vincenza Dolo
Format: Article
Language:English
Published: Elsevier 2006-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Shed membrane vesicles
VEGF
tumor angiogenesis
pH
ovarian cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800187

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