M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

<p>Abstract</p> <p>Background</p> <p>HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen.</p> <p>Findings</p&...

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Main Authors: Selhorst Philippe, Grupping Katrijn, Tong Tommy, Crooks Ema T, Martin Loïc, Vanham Guido, Binley James M, Ariën Kevin K
Format: Article
Language:English
Published: BMC 2013-02-01
Series:Retrovirology
Subjects:
HIV
Entry
CD4 binding site
gp120
Shedding
Inhibition
Online Access:http://www.retrovirology.com/content/10/1/12
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spelling doaj-db75d522eb404586854c84ec051fe4bc2020-11-24T21:40:08ZengBMCRetrovirology1742-46902013-02-011011210.1186/1742-4690-10-12M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 sheddingSelhorst PhilippeGrupping KatrijnTong TommyCrooks Ema TMartin LoïcVanham GuidoBinley James MAriën Kevin K<p>Abstract</p> <p>Background</p> <p>HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen.</p> <p>Findings</p> <p>To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding.</p> <p>Conclusions</p> <p>M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.</p> http://www.retrovirology.com/content/10/1/12HIVEntryCD4 binding sitegp120SheddingInhibition
collection DOAJ
language English
format Article
sources DOAJ
author Selhorst Philippe
Grupping Katrijn
Tong Tommy
Crooks Ema T
Martin Loïc
Vanham Guido
Binley James M
Ariën Kevin K
spellingShingle Selhorst Philippe
Grupping Katrijn
Tong Tommy
Crooks Ema T
Martin Loïc
Vanham Guido
Binley James M
Ariën Kevin K
M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
Retrovirology
HIV
Entry
CD4 binding site
gp120
Shedding
Inhibition
author_facet Selhorst Philippe
Grupping Katrijn
Tong Tommy
Crooks Ema T
Martin Loïc
Vanham Guido
Binley James M
Ariën Kevin K
author_sort Selhorst Philippe
title M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
title_short M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
title_full M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
title_fullStr M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
title_full_unstemmed M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
title_sort m48u1 cd4 mimetic has a sustained inhibitory effect on cell-associated hiv-1 by attenuating virion infectivity through gp120 shedding
publisher BMC
series Retrovirology
issn 1742-4690
publishDate 2013-02-01
description <p>Abstract</p> <p>Background</p> <p>HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen.</p> <p>Findings</p> <p>To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding.</p> <p>Conclusions</p> <p>M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.</p>
topic HIV
Entry
CD4 binding site
gp120
Shedding
Inhibition
url http://www.retrovirology.com/content/10/1/12
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