SPOP mutation induces DNA methylation via stabilizing GLP/G9a
The molecular mechanism underlying the DNA hypermethylation phenotype observed in the SPOP-mutant prostate cancers is unclear. Here, the authors show that mutant SPOP induces global aberrant DNA methylation patterns through GLP/G9a and renders prostate cancer cells susceptible to DNA demethylating a...
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Bibliographic Details
Main Authors: |
Jianong Zhang,
Kun Gao,
Hongyan Xie,
Dejie Wang,
Pingzhao Zhang,
Ting Wei,
Yuqian Yan,
Yunqian Pan,
Wenbin Ye,
Huifen Chen,
Qing Shi,
Yao Li,
Shi-min Zhao,
Xiaonan Hou,
Saravut J. Weroha,
Yuzhuo Wang,
Jun Zhang,
R. Jeffrey Karnes,
Housheng Hansen He,
Liguo Wang,
Chenji Wang,
Haojie Huang |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2021-09-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-021-25951-3
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