SPOP mutation induces DNA methylation via stabilizing GLP/G9a
The molecular mechanism underlying the DNA hypermethylation phenotype observed in the SPOP-mutant prostate cancers is unclear. Here, the authors show that mutant SPOP induces global aberrant DNA methylation patterns through GLP/G9a and renders prostate cancer cells susceptible to DNA demethylating a...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25951-3 |
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doaj-db75dbabc63044e4b2c4d834235492872021-10-03T11:49:48ZengNature Publishing GroupNature Communications2041-17232021-09-0112111710.1038/s41467-021-25951-3SPOP mutation induces DNA methylation via stabilizing GLP/G9aJianong Zhang0Kun Gao1Hongyan Xie2Dejie Wang3Pingzhao Zhang4Ting Wei5Yuqian Yan6Yunqian Pan7Wenbin Ye8Huifen Chen9Qing Shi10Yao Li11Shi-min Zhao12Xiaonan Hou13Saravut J. Weroha14Yuzhuo Wang15Jun Zhang16R. Jeffrey Karnes17Housheng Hansen He18Liguo Wang19Chenji Wang20Haojie Huang21State Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan UniversityDepartment of Clinical Laboratory, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji UniversityDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and ScienceDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and ScienceFudan University Shanghai Cancer Center and Department of Pathology, Shanghai Medical College, Fudan UniversityDivison of Computational Biology, Mayo Clinic College of Medicine and ScienceDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and ScienceDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and ScienceDepartment of Automation, Xiamen UniversityDepartment of Clinical Laboratory, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji UniversityState Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan UniversityState Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan UniversityState Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan UniversityDepartment of Oncology, Mayo Clinic College of MedicineDepartment of Oncology, Mayo Clinic College of MedicineDepartment of Experimental Therapeutics, BC Cancer Research CentreDepartment of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and ScienceDepartment of Urology, Mayo Clinic College of Medicine and ScienceDepartment of Medical Biophysics, University of TorontoDivison of Computational Biology, Mayo Clinic College of Medicine and ScienceState Key Lab of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan UniversityDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and ScienceThe molecular mechanism underlying the DNA hypermethylation phenotype observed in the SPOP-mutant prostate cancers is unclear. Here, the authors show that mutant SPOP induces global aberrant DNA methylation patterns through GLP/G9a and renders prostate cancer cells susceptible to DNA demethylating agents.https://doi.org/10.1038/s41467-021-25951-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jianong Zhang Kun Gao Hongyan Xie Dejie Wang Pingzhao Zhang Ting Wei Yuqian Yan Yunqian Pan Wenbin Ye Huifen Chen Qing Shi Yao Li Shi-min Zhao Xiaonan Hou Saravut J. Weroha Yuzhuo Wang Jun Zhang R. Jeffrey Karnes Housheng Hansen He Liguo Wang Chenji Wang Haojie Huang |
| spellingShingle |
Jianong Zhang Kun Gao Hongyan Xie Dejie Wang Pingzhao Zhang Ting Wei Yuqian Yan Yunqian Pan Wenbin Ye Huifen Chen Qing Shi Yao Li Shi-min Zhao Xiaonan Hou Saravut J. Weroha Yuzhuo Wang Jun Zhang R. Jeffrey Karnes Housheng Hansen He Liguo Wang Chenji Wang Haojie Huang SPOP mutation induces DNA methylation via stabilizing GLP/G9a Nature Communications |
| author_facet |
Jianong Zhang Kun Gao Hongyan Xie Dejie Wang Pingzhao Zhang Ting Wei Yuqian Yan Yunqian Pan Wenbin Ye Huifen Chen Qing Shi Yao Li Shi-min Zhao Xiaonan Hou Saravut J. Weroha Yuzhuo Wang Jun Zhang R. Jeffrey Karnes Housheng Hansen He Liguo Wang Chenji Wang Haojie Huang |
| author_sort |
Jianong Zhang |
| title |
SPOP mutation induces DNA methylation via stabilizing GLP/G9a |
| title_short |
SPOP mutation induces DNA methylation via stabilizing GLP/G9a |
| title_full |
SPOP mutation induces DNA methylation via stabilizing GLP/G9a |
| title_fullStr |
SPOP mutation induces DNA methylation via stabilizing GLP/G9a |
| title_full_unstemmed |
SPOP mutation induces DNA methylation via stabilizing GLP/G9a |
| title_sort |
spop mutation induces dna methylation via stabilizing glp/g9a |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-09-01 |
| description |
The molecular mechanism underlying the DNA hypermethylation phenotype observed in the SPOP-mutant prostate cancers is unclear. Here, the authors show that mutant SPOP induces global aberrant DNA methylation patterns through GLP/G9a and renders prostate cancer cells susceptible to DNA demethylating agents. |
| url |
https://doi.org/10.1038/s41467-021-25951-3 |
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