Loss of immune tolerance to IL-2 in type 1 diabetes

Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker.

Bibliographic Details
Main Authors:	Louis Pérol, John M. Lindner, Pamela Caudana, Nicolas Gonzalo Nunez, Audrey Baeyens, Andrea Valle, Christine Sedlik, Delphine Loirat, Olivier Boyer, Alain Créange, José Laurent Cohen, Ute Christine Rogner, Jun Yamanouchi, Martine Marchant, Xavier Charles Leber, Meike Scharenberg, Marie-Claude Gagnerault, Roberto Mallone, Manuela Battaglia, Pere Santamaria, Agnès Hartemann, Elisabetta Traggiai, Eliane Piaggio
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13027

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spelling	doaj-db770a8739b84dbf870ffd96cace147e2021-05-11T11:17:40ZengNature Publishing GroupNature Communications2041-17232016-10-017111010.1038/ncomms13027Loss of immune tolerance to IL-2 in type 1 diabetesLouis Pérol0John M. Lindner1Pamela Caudana2Nicolas Gonzalo Nunez3Audrey Baeyens4Andrea Valle5Christine Sedlik6Delphine Loirat7Olivier Boyer8Alain Créange9José Laurent Cohen10Ute Christine Rogner11Jun Yamanouchi12Martine Marchant13Xavier Charles Leber14Meike Scharenberg15Marie-Claude Gagnerault16Roberto Mallone17Manuela Battaglia18Pere Santamaria19Agnès Hartemann20Elisabetta Traggiai21Eliane Piaggio22Sorbonne Universités, Pierre and Marie Curie University Paris 06Novartis Institutes for Biomedical ResearchInstitut Curie, PSL Research University, INSERM U932Institut Curie, PSL Research University, INSERM U932Sorbonne Universités, Pierre and Marie Curie University Paris 06Diabetes Research Institute (DRI), IRCCS San Raffaele Scientific InstituteInstitut Curie, PSL Research University, INSERM U932Translational Research Department, SiRIC TransImm Translational Immunotherapy Team, Research Center, PSL Research University, Institut CurieINSERM, U905Service de Neurologie, Groupe Hospitalier Henri Mondor, AP-HPUniversité Paris-Est CréteilDépartement Biologie du développement et cellules souches, Institut Pasteur, CNRS URA 2578Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine. University of CalgaryNovartis Institutes for Biomedical ResearchNovartis Institutes for Biomedical ResearchNovartis Institutes for Biomedical ResearchINSERM, U1016, Cochin Institute, DeAR LabINSERM, U1016, Cochin Institute, DeAR LabDiabetes Research Institute (DRI), IRCCS San Raffaele Scientific InstituteJulia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine. University of CalgaryDepartment of Medicine Faculty, Université Pierre et Marie Curie—Paris 6Novartis Institutes for Biomedical ResearchSorbonne Universités, Pierre and Marie Curie University Paris 06Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker.https://doi.org/10.1038/ncomms13027
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Louis Pérol John M. Lindner Pamela Caudana Nicolas Gonzalo Nunez Audrey Baeyens Andrea Valle Christine Sedlik Delphine Loirat Olivier Boyer Alain Créange José Laurent Cohen Ute Christine Rogner Jun Yamanouchi Martine Marchant Xavier Charles Leber Meike Scharenberg Marie-Claude Gagnerault Roberto Mallone Manuela Battaglia Pere Santamaria Agnès Hartemann Elisabetta Traggiai Eliane Piaggio
spellingShingle	Louis Pérol John M. Lindner Pamela Caudana Nicolas Gonzalo Nunez Audrey Baeyens Andrea Valle Christine Sedlik Delphine Loirat Olivier Boyer Alain Créange José Laurent Cohen Ute Christine Rogner Jun Yamanouchi Martine Marchant Xavier Charles Leber Meike Scharenberg Marie-Claude Gagnerault Roberto Mallone Manuela Battaglia Pere Santamaria Agnès Hartemann Elisabetta Traggiai Eliane Piaggio Loss of immune tolerance to IL-2 in type 1 diabetes Nature Communications
author_facet	Louis Pérol John M. Lindner Pamela Caudana Nicolas Gonzalo Nunez Audrey Baeyens Andrea Valle Christine Sedlik Delphine Loirat Olivier Boyer Alain Créange José Laurent Cohen Ute Christine Rogner Jun Yamanouchi Martine Marchant Xavier Charles Leber Meike Scharenberg Marie-Claude Gagnerault Roberto Mallone Manuela Battaglia Pere Santamaria Agnès Hartemann Elisabetta Traggiai Eliane Piaggio
author_sort	Louis Pérol
title	Loss of immune tolerance to IL-2 in type 1 diabetes
title_short	Loss of immune tolerance to IL-2 in type 1 diabetes
title_full	Loss of immune tolerance to IL-2 in type 1 diabetes
title_fullStr	Loss of immune tolerance to IL-2 in type 1 diabetes
title_full_unstemmed	Loss of immune tolerance to IL-2 in type 1 diabetes
title_sort	loss of immune tolerance to il-2 in type 1 diabetes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-10-01
description	Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker.
url	https://doi.org/10.1038/ncomms13027
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Loss of immune tolerance to IL-2 in type 1 diabetes

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