Comprehensive network modeling from single cell RNA sequencing of human and mouse reveals well conserved transcription regulation of hematopoiesis

Comprehensive network modeling from single cell RNA sequencing of human and mouse reveals well conserved transcription regulation of hematopoiesis

Abstract Background Presently, there is no comprehensive analysis of the transcription regulation network in hematopoiesis. Comparison of networks arising from gene co-expression across species can facilitate an understanding of the conservation of functional gene modules in hematopoiesis. Results W...

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Bibliographic Details
Main Authors: Shouguo Gao, Zhijie Wu, Xingmin Feng, Sachiko Kajigaya, Xujing Wang, Neal S. Young
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Genomics
Subjects:
Hematopoiesis
Gene regulatory network
Co-expression network
Single-cell RNA sequencing
Cross-species network analysis
Online Access:https://doi.org/10.1186/s12864-020-07241-2

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